Usp21 ubiquitin specific peptidase 21 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Usp21provided by RGD
Official Full Name: ubiquitin specific peptidase 21provided by RGD
Primary source: RGD:1588822
See related: EnsemblRapid:ENSRNOG00000038347 AllianceGenome:RGD:1588822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cysteine-type deubiquitinase activity; deNEDDylase activity; and transcription coactivator activity. Involved in neuron projection development. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human USP21 (ubiquitin specific peptidase 21). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 84.5), Spleen (RPKM 59.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (86235122..86241663, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (83702672..83709215, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (89655016..89661150, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Studies indicate a key role for USP21 in the governance of microtubule- and centrosome-associated physiological processes.
Title: Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139112 (e-PCR)
- UniSTS:221198

RH127964 (e-PCR)
- UniSTS:211274

BI294933 (e-PCR)
- UniSTS:246158

BF405831 (e-PCR)
- UniSTS:247970

W53272 (e-PCR), detects polymorphism
- UniSTS:143014

G43283 (e-PCR)
- UniSTS:94919

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type deubiquitinase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deNEDDylase activity	IEA Inferred from Electronic Annotation more info
enables deNEDDylase activity	ISO Inferred from Sequence Orthology more info
enables deNEDDylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein deubiquitination	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation-coupled chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation-coupled chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 21

Names: deubiquitinating enzyme 21; ubiquitin thioesterase 21; ubiquitin thiolesterase 21; ubiquitin-specific protease 21; ubiquitin-specific-processing protease 21

NP_001121110.1

EC 3.4.19.12

XP_063128688.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127638.2 → NP_001121110.1 ubiquitin carboxyl-terminal hydrolase 21

See identical proteins and their annotated locations for NP_001121110.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

B2GUX4

UniProtKB/TrEMBL

A0A8I6A1T1

Related

ENSRNOP00000055192.5, ENSRNOT00000058390.5

Conserved Domains (2) summary

cd02674
Location:213 → 556

Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam00443
Location:212 → 555

UCH; Ubiquitin carboxyl-terminal hydrolase