Rnf10 ring finger protein 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rnf10provided by RGD
Official Full Name: ring finger protein 10provided by RGD
Primary source: RGD:1309282
See related: EnsemblRapid:ENSRNOG00000001172 AllianceGenome:RGD:1309282
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables transcription cis-regulatory region binding activity. Involved in positive regulation of transcription by RNA polymerase II; postsynapse to nucleus signaling pathway; and regulation of nervous system development. Located in nucleus. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic density membrane. Orthologous to human RNF10 (ring finger protein 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 454.8), Muscle (RPKM 242.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q16

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (47002409..47036201)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (41341708..41375505)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (47103313..47137096)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis.
Title: RING Finger Protein 10 Regulates AP-1/Meox2 to Mediate Pirarubicin-Induced Cardiomyocyte Apoptosis.
protein kinase C [PKC]-dependent phosphorylation of RNF10 Ser31 was identified as a key step for RNF10 detachment from NMDA receptor and its subsequent trafficking to the nucleus.
Title: The Synaptonuclear Messenger RNF10 Acts as an Architect of Neuronal Morphology.
The differential expression of RNF10 had a completely opposite effect on vascular damage under hyperglycaemia, further displaying the core function of RNF10 in regulating vascular remodeling induced by diabetes.
Title: RING finger protein 10 is a potential drug target for diabetic vascular complications.
Low RNF10 expression is associated with neointimal hyperplasia.
Title: RING finger protein 10 prevents neointimal hyperplasia by promoting apoptosis in vitro and in vivo.

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General gene information

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Markers

RH144528 (e-PCR)
- UniSTS:233773

RH135502 (e-PCR)
- UniSTS:164932

BF397929 (e-PCR)
- UniSTS:246388

RH129378 (e-PCR)
- UniSTS:212685

BF405038 (e-PCR)
- UniSTS:247771

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in negative regulation of Schwann cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myelination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein monoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein monoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosome-associated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ribosome-associated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ribosome-associated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	IEA Inferred from Electronic Annotation more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
is_active_in extrinsic component of postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of postsynaptic density membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF10

NP_001011904.1

EC 2.3.2.27

NP_001402711.1

EC 2.3.2.27

XP_063127285.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.