Slfn4 schlafen family member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slfn4provided by RGD
Official Full Name: schlafen family member 4provided by RGD
Primary source: RGD:620455
See related: AllianceGenome:RGD:620455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Slfn3; Cdk107
Summary: Predicted to enable RNA nuclease activity and ribosome binding activity. Involved in lung alveolus development. Predicted to be located in cytosol and nucleus. Orthologous to several human genes including SLFN12 (schlafen family member 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 462.2), Lung (RPKM 285.9) and 7 other tissues See more
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Genomic context

Location:: 10q26

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (68492135..68515674)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (67994601..68018141)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (70411686..70435162)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Slfn3 is an important regulator of the rat intestinal epithelial phenotype, and may represent a novel common pathway for the regulation of intestinal epithelial differentiation.
Title: Regulation of epithelial differentiation in rat intestine by intraluminal delivery of an adenoviral vector or silencing RNA coding for Schlafen 3.
Slfn2 and Slfn3 play essential roles in the control of mouse malignant melanoma cell proliferation and/or anchorage-independent growth
Title: Expression and regulatory effects of murine Schlafen (Slfn) genes in malignant melanoma and renal cell carcinoma.
our present data suggest that Slfn-3 inhibits multiple cancer stem cell characteristics of FOLFOX-resistant colon cancer stem-like cells.
Title: Schlafen-3 decreases cancer stem cell marker expression and autocrine/juxtacrine signaling in FOLFOX-resistant colon cancer cells.
Intestinal Slfn3 expression was increased substantially after birth (2.1- +/- .5-fold) and on days 1 and 5 (P < .02). Slfn3 was higher after birth in liver and lung but decreased sharply thereafter.
Title: Schlafen 3 changes during rat intestinal maturation.
These results suggest that cyclic strain induces an absorptive phenotype characterized by increased dipeptidyl dipeptidase activity via enzymatic induction of Schlafen 3 in rat IEC-6 cells.
Title: Schlafen 3 induction by cyclic strain regulates intestinal epithelial differentiation.
Slfn3 could have a role in T cell differentiation and activation.
Title: Characterization of Schlafen-3 expression in effector and regulatory T cells.
Slfn-3 plays a critical role in regulating intestinal mucosal differentiation.
Title: Schlafen-3: a novel regulator of intestinal differentiation.
Schlafen 3, a novel negative regulator of growth, which is markedly downregulated in the colonic mucosa of the aged, may play a role in regulating colonic mucosal growth during aging.
Title: Schlafen 3, a novel gene, regulates colonic mucosal growth during aging.

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General gene information

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Markers

D10Chm244 (e-PCR)
- UniSTS:518208

D10Chm179 (e-PCR)
- UniSTS:518229

D10Mco86 (e-PCR)
- UniSTS:519015

AU046963 (e-PCR)
- UniSTS:110975

RH132185 (e-PCR)
- UniSTS:215468

D10Wox51 (e-PCR)
- UniSTS:517863

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA nuclease activity	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lung alveolus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in rRNA catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: schlafen family member 4

Names: schlafen 3; schlafen 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430210.1 → NP_001417139.1 schlafen family member 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K4S0, A0A0G2K750, Q9TPX1
NM_053687.2 → NP_446139.1 schlafen family member 4

See identical proteins and their annotated locations for NP_446139.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K4S0, A0A0G2K750, Q9TPX1

Conserved Domains (1) summary

PHA02782
Location:47 → 329

PHA02782; hypothetical protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

68492135..68515674

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008767933.4 → XP_008766155.1 schlafen family member 4 isoform X1

Conserved Domains (1) summary

PHA02782
Location:47 → 329

PHA02782; hypothetical protein; Provisional
XM_039085031.2 → XP_038940959.1 schlafen family member 4 isoform X1

UniProtKB/TrEMBL

A0A0G2K4S0, A0A0G2K750, Q9TPX1

Conserved Domains (1) summary

PHA02782
Location:47 → 329

PHA02782; hypothetical protein; Provisional
XM_017596949.3 → XP_017452438.1 schlafen family member 4 isoform X2

UniProtKB/TrEMBL

A0A0G2K4S0