Fcgr2b Fc gamma receptor 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fcgr2bprovided by RGD
Official Full Name: Fc gamma receptor 2Bprovided by RGD
Primary source: RGD:631331
See related: EnsemblRapid:ENSRNOG00000046452 AllianceGenome:RGD:631331
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CD32; FCRII; Fcgr2; FcgammaRIIB2
Summary: Enables IgG binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of neutrophil apoptotic process; and regulation of response to endoplasmic reticulum stress. Located in cell surface and recycling endosome. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dengue disease (multiple); hematologic cancer (multiple); leukopenia (multiple); and malaria (multiple). Orthologous to several human genes including FCGR2B (Fc gamma receptor IIb). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 492.4), Spleen (RPKM 271.0) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (85725897..85740517, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (83191253..83207778, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (89329298..89343916, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data shew that he up-regulation of Fc gamma RIIB (FcgammaRIIB) expression in macrophages might suppress cell phagocytosis and chemotaxis.
Title: [Up-regulated expression of FcγRIIB inhibits phagocytosis and chemotaxis of macrophages].
These results are consistent with a model where mAb BGD6 binds through its Fab portion to a approximately 110 kDa protein and the Fc tail interacts with Fc gamma RIIB (CD32).[Fc gamma RIIB]
Title: The low affinity IgG receptor Fc gamma RIIB contributes to the binding of the mast cell specific antibody, mAb BGD6.
FcgammaRIIb2 in rat liver sinusoidal endothelial cells is used as both a recycling receptor and a receptor for efficient immune complexes clearance.
Title: Receptor-mediated endocytosis of immune complexes in rat liver sinusoidal endothelial cells is mediated by FcgammaRIIb2.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141624 (e-PCR)
- UniSTS:223618

AU046896 (e-PCR)
- UniSTS:111033

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables IgG binding	IBA Inferred from Biological aspect of Ancestor more info
enables IgG binding	IDA Inferred from Direct Assay more info	PubMed
enables IgG binding	ISO Inferred from Sequence Orthology more info
enables IgG receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables immunoglobulin binding	IDA Inferred from Direct Assay more info	PubMed
enables low-affinity IgG receptor activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in Fc receptor-mediated immune complex endocytosis	ISO Inferred from Sequence Orthology more info
involved_in Fc-gamma receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in antibody-dependent cellular cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within antigen processing and presentation of exogenous peptide antigen via MHC class II	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to molecule of bacterial origin	ISO Inferred from Sequence Orthology more info
involved_in cerebellum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response	ISO Inferred from Sequence Orthology more info
involved_in dendrite development	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in immune complex clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in immune effector process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within mast cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of acute inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neutrophil apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of type I hypersensitivity	ISO Inferred from Sequence Orthology more info
acts_upstream_of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phagocytosis, engulfment	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor-mediated endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: low affinity immunoglobulin gamma Fc region receptor II

Names: FC-gamma RII; Fc fragment of IgG receptor IIb; Fc fragment of IgG, low affinity IIb, receptor; Fc gamma receptor IIb; Fc receptor, IgG, low affinity IIb; igG Fc receptor II beta; low affinity immunoglobulin gamma Fc region receptor II-b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175756.3 → NP_786932.2 low affinity immunoglobulin gamma Fc region receptor II precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q63203

UniProtKB/TrEMBL

Q5BKD6

Related

ENSRNOP00000075099.3, ENSRNOT00000091541.3

Conserved Domains (1) summary

smart00409
Location:136 → 212

IG; Immunoglobulin

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

85725897..85740517 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006250235.3 → XP_006250297.1 low affinity immunoglobulin gamma Fc region receptor II isoform X3

See identical proteins and their annotated locations for XP_006250297.1

UniProtKB/Swiss-Prot

Q63203

UniProtKB/TrEMBL

A6IDR2, Q5BKD6

Conserved Domains (3) summary

cd05753
Location:129 → 211

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:135 → 211

IG_like; Immunoglobulin like

cl11960
Location:47 → 125

Ig; Immunoglobulin domain
XM_017598710.3 → XP_017454199.1 low affinity immunoglobulin gamma Fc region receptor II isoform X2

UniProtKB/TrEMBL

A6IDR3, A6IDR4

Conserved Domains (3) summary

cd05753
Location:129 → 211

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:135 → 211

IG_like; Immunoglobulin like

cl11960
Location:47 → 125

Ig; Immunoglobulin domain
XM_039090504.2 → XP_038946432.1 low affinity immunoglobulin gamma Fc region receptor II isoform X4

UniProtKB/TrEMBL

A0A0G2K9R6

Conserved Domains (3) summary

cd00096
Location:49 → 52

Ig; Ig strand A [structural motif]

cd05753
Location:130 → 212

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs), and similar domains

cl11960
Location:48 → 126

Ig; Immunoglobulin domain
XM_006250233.3 → XP_006250295.1 low affinity immunoglobulin gamma Fc region receptor II isoform X1

See identical proteins and their annotated locations for XP_006250295.1

UniProtKB/TrEMBL

A3RLA8, A6IDR3

Related

ENSRNOP00000055293.2, ENSRNOT00000058497.5

Conserved Domains (3) summary

cd05753
Location:130 → 212

Ig2_FcgammaR_like; Second immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins

smart00410
Location:136 → 212

IG_like; Immunoglobulin like

cl11960
Location:48 → 126

Ig; Immunoglobulin domain