Agps alkylglycerone phosphate synthase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Agpsprovided by RGD
Full Name: alkylglycerone phosphate synthaseprovided by RGD
Primary source: RGD:620364
See related: EnsemblRapid:ENSRNOG00000001547 AllianceGenome:RGD:620364
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ads; Adps; Adap-s
Summary: Enables alkylglycerone-phosphate synthase activity. Predicted to be involved in ether lipid biosynthetic process. Located in peroxisome. Human ortholog(s) of this gene implicated in rhizomelic chondrodysplasia punctata and rhizomelic chondrodysplasia punctata type 3. Orthologous to human AGPS (alkylglycerone phosphate synthase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 373.9), Lung (RPKM 257.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q23

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (81154599..81253099)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (60747323..60845831)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (62648352..62749250)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FAD binding	IEA Inferred from Electronic Annotation more info
enables FAD binding	ISS Inferred from Sequence or Structural Similarity more info
enables alkylglycerone-phosphate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkylglycerone-phosphate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables alkylglycerone-phosphate synthase activity	IEA Inferred from Electronic Annotation more info
enables alkylglycerone-phosphate synthase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ether lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ether lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in peroxisomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: alkyldihydroxyacetonephosphate synthase, peroxisomal

Names: alkyl-DHAP synthase; alkyl-dihydroxyacetonephosphate synthase; alkyldihydroxyacetone phosphate synthase

NP_445802.2

EC 2.5.1.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053350.2 → NP_445802.2 alkyldihydroxyacetonephosphate synthase, peroxisomal

Status: VALIDATED

Source sequence(s)

AF121052, BF524961, BM389725

UniProtKB/TrEMBL

A0A8I5ZN98, A6HMG2

Related

ENSRNOP00000079560.1, ENSRNOT00000096806.2

Conserved Domains (3) summary

COG0277
Location:212 → 664

GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]

pfam01565
Location:218 → 361

FAD_binding_4; FAD binding domain

pfam02913
Location:396 → 669

FAD-oxidase_C; FAD linked oxidases, C-terminal domain