Eef1a1 eukaryotic translation elongation factor 1 alpha 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Eef1a1provided by RGD
Official Full Name: eukaryotic translation elongation factor 1 alpha 1provided by RGD
Primary source: RGD:67387
See related: EnsemblRapid:ENSRNOG00000009439 AllianceGenome:RGD:67387
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SI; EF1A; EEF-1; EEF1A; Eef1a2; Eef1a2l1
Summary: Enables heterocyclic compound binding activity; identical protein binding activity; and mRNA binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of reactive oxygen species biosynthetic process; and regulation of postsynaptic specialization assembly. Is active in GABA-ergic synapse and postsynapse. Orthologous to human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 26871.9), Thymus (RPKM 23830.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (88221839..88225688, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (79341554..79344784, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (85838594..85841816, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

eEF1alpha-cytoskeleton interactions play a role in perinuclear mRNA localization.
Title: Elongation factor 1alpha binds to the region of the metallothionein-1 mRNA implicated in perinuclear localization--importance of an internal stem-loop.
Glutamate exerts an exquisite time-dependent translational control in glial cells, a process that might be critical for glia-neuron interactions in Bergmann glial cells.
Title: Glutamate regulates eEF1A phosphorylation and ribosomal transit time in Bergmann glial cells.
5-bp internal stem in the metallothionein-1 3'UTR is critical for binding of eEF1alpha and histidine-tRNA ligase, and that binding of eEF1alpha is facilitated through domains I and III.
Title: Fine mapping of interactions between eEF1alpha protein and 3'UTR of metallothionein-1 mRNA.
EF and GAPDH were identified as the most stable reference genes in auditory cortex and cochlea, respectively.
Title: Identifying stable reference genes for evaluation of antioxidative enzyme gene expression in auditory cortex and cochlea of young and old Fischer 344 rats.
eEF1A is coupled to both inhibitory and excitatory receptors, in a process that may involve the ERK-signaling pathway
Title: Components of the translational machinery are associated with juvenile glycine receptors and are redistributed to the cytoskeleton upon aging and synaptic activity.
eEF1A is enriched in the rat cerebellar postsynaptic density (PSD) fraction and is tightly associated with the PSD 'core', colocalizing with the PSD marker PSD95 in dissociated cerebellar cultures and immunoelectron microscopy of adult rat cerebellum.
Title: Presence of translation elongation factor-1A in the rat cerebellar postsynaptic density.
mRNA for eEF1A is present in pyramidal cell dendrites and that the LTP-associated increase in eEF1A expression was intact in dendrites that had been severed from their cell bodies.
Title: Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation.
stimulation of translation by nerve growth factor
Title: Nerve growth factor specifically stimulates translation of eukaryotic elongation factor 1A-1 (eEF1A-1) mRNA by recruitment to polyribosomes in PC12 cells.
novel role for M4 (Chrm4) in the regulation of protein synthesis through its interaction with eEF1A2.
Title: Novel interaction between the M4 muscarinic acetylcholine receptor and elongation factor 1A2.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

EEF1A1 (e-PCR)
- UniSTS:278329

ECD01636 (e-PCR)
- UniSTS:282737

D1S3313 (e-PCR)
- UniSTS:63106

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activator activity	ISO Inferred from Sequence Orthology more info
enables kinase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables tRNA binding	ISO Inferred from Sequence Orthology more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	ISO Inferred from Sequence Orthology more info
enables translation elongation factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to nerve growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of reactive oxygen species biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic specialization assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic specialization assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational elongation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	ISO Inferred from Sequence Orthology more info
involved_in translational elongation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	TAS Traceable Author Statement more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in ribosome	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: elongation factor 1-alpha 1

Names: EF-1 alpha2; EF-1-alpha-1; EF-Tu; eEF1A-1; elongation factor 1 A-1; elongation factor Tu; eukaryotic elongation factor 1 A-1; eukaryotic translation elongation factor 1 alpha 2 like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175838.2 → NP_787032.1 elongation factor 1-alpha 1

See identical proteins and their annotated locations for NP_787032.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P20001, P62630, Q5BJW8, Q64718, Q78ED4

UniProtKB/TrEMBL

A0A8L2Q996, A6I1K3

Related

ENSRNOP00000013608.4, ENSRNOT00000013608.8

Conserved Domains (1) summary

PTZ00141
Location:1 → 460

PTZ00141; elongation factor 1- alpha; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

88221839..88225688 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063264828.1 → XP_063120898.1 elongation factor 1-alpha 1 isoform X1

UniProtKB/Swiss-Prot

P20001, P62630, Q5BJW8, Q64718, Q78ED4

UniProtKB/TrEMBL

A0A8L2Q996, A6I1K3
XM_063264829.1 → XP_063120899.1 elongation factor 1-alpha 1 isoform X1

UniProtKB/Swiss-Prot

P20001, P62630, Q5BJW8, Q64718, Q78ED4

UniProtKB/TrEMBL

A0A8L2Q996, A6I1K3
XM_039080748.2 → XP_038936676.1 elongation factor 1-alpha 1 isoform X1

UniProtKB/Swiss-Prot

P20001, P62630, Q5BJW8, Q64718, Q78ED4

UniProtKB/TrEMBL

A0A8L2Q996, A6I1K3

Conserved Domains (1) summary

PTZ00141
Location:1 → 460

PTZ00141; elongation factor 1- alpha; Provisional
XM_039080749.2 → XP_038936677.1 elongation factor 1-alpha 1 isoform X1

UniProtKB/Swiss-Prot

P20001, P62630, Q5BJW8, Q64718, Q78ED4

UniProtKB/TrEMBL

A0A8L2Q996, A6I1K3

Conserved Domains (1) summary

PTZ00141
Location:1 → 460

PTZ00141; elongation factor 1- alpha; Provisional