Nup50 nucleoporin 50 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nup50provided by RGD
Official Full Name: nucleoporin 50provided by RGD
Primary source: RGD:3191
See related: EnsemblRapid:ENSRNOG00000013423 AllianceGenome:RGD:3191
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rtp60; Npap60
Summary: Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within neural tube formation. Part of nuclear pore. Orthologous to human NUP50 (nucleoporin 50). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 249.3), Thymus (RPKM 183.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (117927882..117945155)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (116047960..116065231)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (125833557..125850830)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128216 (e-PCR)
- UniSTS:211524

RH143791 (e-PCR)
- UniSTS:233037

Nup50 (e-PCR), detects polymorphism
- UniSTS:144049

RH128347 (e-PCR)
- UniSTS:211655

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in intracellular transport	IEA Inferred from Electronic Annotation more info
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in neural tube formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural tube formation	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear pore complex protein Nup50

Names: 50 kDa nucleoporin; Nucleoprotein 50kD; nuclear pore associated protein; nucleoporin 50 kDa; nucleoporin Nup50; nucleoprotein 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012991.2 → NP_037123.2 nuclear pore complex protein Nup50

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000007

UniProtKB/Swiss-Prot

O08587, Q4QR93

UniProtKB/TrEMBL

A6HTC6, G3V7R1

Related

ENSRNOP00000018155.4, ENSRNOT00000018155.8

Conserved Domains (2) summary

cd13170
Location:349 → 465

RanBD_NUP50; Nucleoporin 50 Ran-binding domain

pfam08911
Location:3 → 64

NUP50; NUP50 (Nucleoporin 50 kDa)