Stat5a signal transducer and activator of transcription 5A [ Rattus norvegicus (Norway rat) ]

Gene ID: 24918, updated on 9-Dec-2024

Summary

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Official Symbol: Stat5aprovided by RGD
Official Full Name: signal transducer and activator of transcription 5Aprovided by RGD
Primary source: RGD:3773
See related: EnsemblRapid:ENSRNOG00000019496 AllianceGenome:RGD:3773
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Stat5
Summary: Enables DNA-binding transcription factor activity; double-stranded DNA binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; mammary gland development; and response to ethanol. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human STAT5A (signal transducer and activator of transcription 5A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 184.7), Muscle (RPKM 150.3) and 9 other tissues See more
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Genomic context

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See Stat5a in Genome Data Viewer

Location:: 10q31

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86285859..86310187)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85785537..85809869)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88764732..88789060)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prolactin Regulates Testicular Gene Expression and Cell Cycle Processes Predominantly via JAK2/STAT5 Pathway in the Male Rat.
Title: Prolactin Regulates Testicular Gene Expression and Cell Cycle Processes Predominantly via JAK2/STAT5 Pathway in the Male Rat.
Silencing of Long Noncoding RNA GAS5 Blocks Experimental Cerebral Ischemia-Reperfusion Injury by Restraining AQP4 Expression via the miR-1192/STAT5A Axis.
Title: Silencing of Long Noncoding RNA GAS5 Blocks Experimental Cerebral Ischemia-Reperfusion Injury by Restraining AQP4 Expression via the miR-1192/STAT5A Axis.
STAT5A modulated EndMT via upregulation of ELTD1 expression in diabetic nephropathy.
Title: STAT5A modulated EndMT via upregulation of ELTD1 expression in diabetic nephropathy.
MEHP promotes liver fibrosis by down-regulating STAT5A in BRL-3A hepatocytes.
Title: MEHP promotes liver fibrosis by down-regulating STAT5A in BRL-3A hepatocytes.
The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells.
Title: The RAGE/STAT5/autophagy axis regulates senescence in mesangial cells.
MRTF-A overexpression synergistically enhanced the induction of FN and ICAM-1 by Advanced glycation end products.
Title: MRTF-A mediated FN and ICAM-1 expression in AGEs-induced rat glomerular mesangial cells via activating STAT5.
found that phosphorylated STAT5 was expressed in almost all oxytocin neurones of late-pregnant and lactating rats but was almost absent from oxytocin neurones of virgin rats.
Title: Reproductive Regulation of Gene Expression in the Hypothalamic Supraoptic and Paraventricular Nuclei.
STAT3/miR-211/STAT5A signaling plays a key role in mesenchymal stem cell migration.
Title: MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy.
results suggest that a subpopulation of TLR4-activated microglia may survive by producing GM-CSF and up-regulating GM-CSFR. This autocrine GM-CSF pathway may activate the JAK2/STAT5 signaling pathway
Title: The Toll-like receptor 4-activated neuroprotective microglia subpopulation survives via granulocyte macrophage colony-stimulating factor and JAK2/STAT5 signaling.
Basal renal IL6 mRNA and phosphorylation of its downstream signaling molecule STAT3 were increased as was the product of its action, the suppressor of cytokine signaling 3 (SOCS3) mRNA.
Title: Impaired renal growth hormone JAK/STAT5 signaling in chronic kidney disease.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphate ion binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Peyer's patch development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to granulocyte macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within development of secondary female sexual characteristics	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within development of secondary male sexual characteristics	ISO Inferred from Sequence Orthology more info
involved_in eosinophil differentiation	IEA Inferred from Electronic Annotation more info
involved_in eosinophil differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell differentiation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within female pregnancy	ISO Inferred from Sequence Orthology more info
acts_upstream_of gamma-delta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in interleukin-15-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-15-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-2-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-2-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-3-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-3-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-4-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-4-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-5-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-5-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-7-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-7-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-9-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-9-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in lactation	IEA Inferred from Electronic Annotation more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lactation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid storage	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within luteinization	ISO Inferred from Sequence Orthology more info
acts_upstream_of lymphocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mammary gland epithelium development	ISO Inferred from Sequence Orthology more info
involved_in mammary gland involution	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of mast cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of mast cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mast cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of myeloid cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T-helper 17 cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mast cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of lymphocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mast cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mast cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland epithelium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in reelin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reelin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to peptide hormone	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect taurine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in thrombopoietin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal transducer and activator of transcription 5A

Names: mammary gland factor; signal transducer and activator of transcription 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017064.2 → NP_058760.2 signal transducer and activator of transcription 5A

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q62771

UniProtKB/TrEMBL

A6HJ62, G3V8K7

Related

ENSRNOP00000026662.2, ENSRNOT00000026662.5

Conserved Domains (4) summary

cd10421
Location:573 → 712

SH2_STAT5a; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5a proteins

cd16855
Location:139 → 330

STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)

cd16849
Location:332 → 489

STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

pfam02865
Location:4 → 124

STAT_int; STAT protein, protein interaction domain