Prl3d4 prolactin family 3, subfamily D, member 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prl3d4provided by RGD
Official Full Name: prolactin family 3, subfamily D, member 4provided by RGD
Primary source: RGD:2428
See related: EnsemblRapid:ENSRNOG00000016792 AllianceGenome:RGD:2428
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Csh1v; Pl-Iv; Csh1l1
Summary: Enables prolactin receptor binding activity. Involved in activation of Janus kinase activity and positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 17p12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (37534198..37541035, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (37325804..37332641, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (39271883..39278716, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that demethylation in PL-Iv upstream region is induced at early stage of placental development; once 5'-flanking region of PL-Iv gene has been demethylated, this status continues throughout gestation.
Title: DNA methylation contributes to the tissue-specific expression of the rPL-Iv gene.

Submit: New GeneRIF Correction

General gene information

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Markers

RH129788 (e-PCR)
- UniSTS:213080

BI277906 (e-PCR)
- UniSTS:243910

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables prolactin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables prolactin receptor binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of Janus kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in mammary gland development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lactation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prolactin-3D4

Names: Chorionic somatomammotropin hormone 1 variant; Placental lactogen-1; chorionic somatomammotropin hormone 1-like 1; placental lactogen I; placental lactogen-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033233.1 → NP_150236.1 prolactin-3D4 precursor

See identical proteins and their annotated locations for NP_150236.1

Status: PROVISIONAL

Source sequence(s)

U32679

UniProtKB/Swiss-Prot

P34207, Q4QRA7

UniProtKB/TrEMBL

A0A0H2UHN4, A6J7R5

Related

ENSRNOP00000068935.1, ENSRNOT00000082821.3

Conserved Domains (1) summary

cd10288
Location:24 → 223

prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones