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    ID2-AS1 ID2 antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100506299, updated on 22-Oct-2024

    Summary

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    Official Symbol
    ID2-AS1provided by HGNC
    Official Full Name
    ID2 antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:51103
    See related
    Ensembl:ENSG00000235092 AllianceGenome:HGNC:51103
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in testis (RPKM 1.8), thyroid (RPKM 1.6) and 25 other tissues See more
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    Genomic context

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    See ID2-AS1 in Genome Data Viewer
    Location:
    2p25.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (8670984..8681863, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (8694710..8705586, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (8811114..8821993, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1814 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8712051-8712630 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15270 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15271 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15272 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8723860-8724539 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8724540-8725218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:8727462-8728114 Neighboring gene uncharacterized LOC105373411 Neighboring gene SNRPE pseudogene 5 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:8773308-8774507 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8777331-8777854 Neighboring gene VISTA enhancer hs1527 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:8802380-8803579 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8815873-8816791 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8816792-8817709 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:8818423-8818956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8818957-8819490 Neighboring gene NANOG hESC enhancer GRCh37_chr2:8821385-8821888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8824708-8825498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:8825499-8826288 Neighboring gene inhibitor of DNA binding 2 Neighboring gene kinase D interacting substrate 220 Neighboring gene ARF like GTPase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer. Zhang L, et al. Medicine (Baltimore), 2022 Jul 1. PMID 35776987, Free PMC Article
    2. Down-Regulation of ID2-AS1 Alleviates the Neuronal Injury Induced by 1-Methy1-4-Phenylpyridinium in Human Neuroblastoma Cell Line SH-SY5Y Cells Through Regulating miR-199a-5p/IFNAR1/JAK2/STAT1 Axis. Xu F, et al. Neurochem Res, 2021 Aug. PMID 34050453
    3. LncRNA ID2-AS1 suppresses tumor metastasis by activating the HDAC8/ID2 pathway in hepatocellular carcinoma. Zhou Y, et al. Cancer Lett, 2020 Jan 28. PMID 31730902
    4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer.
      Title: Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer.
    2. Down-Regulation of ID2-AS1 Alleviates the Neuronal Injury Induced by 1-Methy1-4-Phenylpyridinium in Human Neuroblastoma Cell Line SH-SY5Y Cells Through Regulating miR-199a-5p/IFNAR1/JAK2/STAT1 Axis.
      Title: Down-Regulation of ID2-AS1 Alleviates the Neuronal Injury Induced by 1-Methy1-4-Phenylpyridinium in Human Neuroblastoma Cell Line SH-SY5Y Cells Through Regulating miR-199a-5p/IFNAR1/JAK2/STAT1 Axis.
    3. ID2-AS1 significantly suppressed the migration, invasion and metastasis of hepatocellular carcinoma (HCC) cells in vitro and in vivo. Mechanistically, ID2-AS1 regulated the transcription of its adjacent gene inhibitor of DNA binding 2 (ID2) by blocking the binding of histone deacetylase 8 (HDAC8) on the ID2 enhancer
      Title: LncRNA ID2-AS1 suppresses tumor metastasis by activating the HDAC8/ID2 pathway in hepatocellular carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • ID2 antisense RNA 1 (head to head)

    Clone Names

    • AC011747.7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_110153.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AA970710, AI022540, AI034463, DB336412, HY143594
      Related
      ENST00000844151.1

    2. NR_110154.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and contains three alternate 3' exons, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AA399274, CN314431, DA317685

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      8670984..8681863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      8694710..8705586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials