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    MOB2 MOB kinase activator 2 [ Homo sapiens (human) ]

    Gene ID: 81532, updated on 27-Nov-2024

    Summary

    Official Symbol
    MOB2provided by HGNC
    Official Full Name
    MOB kinase activator 2provided by HGNC
    Primary source
    HGNC:HGNC:24904
    See related
    Ensembl:ENSG00000182208 MIM:611969; AllianceGenome:HGNC:24904
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HCCA2
    Summary
    Predicted to enable protein kinase activator activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within actin cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Annotation information
    Annotation category: partial on reference assembly
    Expression
    Ubiquitous expression in skin (RPKM 12.1), endometrium (RPKM 11.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MOB2 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1469448..1486779, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1543884..1615049, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1490678..1508009, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1374637-1375384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1380465-1380966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1380967-1381466 Neighboring gene long intergenic non-protein coding RNA 2689 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3054 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1405373-1405546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3055 Neighboring gene MPRA-validated peak1160 silencer Neighboring gene BR serine/threonine kinase 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1458078-1458816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1469339-1469838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1474249-1474958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1479210-1479772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1520757-1521279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1528327-1529160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1529995-1530826 Neighboring gene uncharacterized LOC124902607 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1534293-1534794 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1534795-1535294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1541250-1541750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1541751-1542251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4289 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1547587-1548086 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1553250-1553750 Neighboring gene uncharacterized LOC124902608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1576597-1577394 Neighboring gene dual specificity phosphatase 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    MOB kinase activator 2
    Names
    MOB2 Mps One Binder homolog
    Mps one binder kinase activator-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172223.3NP_001165694.1  MOB kinase activator 2 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC091196, AK296658, AW874617, BC047291, DC413532
      Consensus CDS
      CCDS53591.1
      UniProtKB/Swiss-Prot
      Q70IA6
      Related
      ENSP00000328694.6, ENST00000329957.7
      Conserved Domains (1) summary
      pfam03637
      Location:63231
      Mob1_phocein; Mob1/phocein family
    2. NM_053005.5NP_443731.2  MOB kinase activator 2 isoform 2

      See identical proteins and their annotated locations for NP_443731.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AW874617, BC047291, BC067785, BP388313, DC413532, HY032250
      UniProtKB/Swiss-Prot
      B4DKP3, Q70IA6, Q96M67
      Conserved Domains (1) summary
      pfam03637
      Location:32200
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      1469448..1486779 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791792.1 Reference GRCh38.p14 PATCHES

      Range
      203714..274494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333117.1XP_054189092.1  MOB kinase activator 2 isoform X3

    2. XM_054333119.1XP_054189094.1  MOB kinase activator 2 isoform X5

    3. XM_054333116.1XP_054189091.1  MOB kinase activator 2 isoform X2

    4. XM_054333115.1XP_054189090.1  MOB kinase activator 2 isoform X1

    5. XM_054333120.1XP_054189095.1  MOB kinase activator 2 isoform X6

    6. XM_054333121.1XP_054189096.1  MOB kinase activator 2 isoform X7

    7. XM_054333118.1XP_054189093.1  MOB kinase activator 2 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      1543884..1615049 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370056.1XP_054226031.1  MOB kinase activator 2 isoform X9

    2. XM_054370058.1XP_054226033.1  MOB kinase activator 2 isoform X11

    3. XM_054370055.1XP_054226030.1  MOB kinase activator 2 isoform X8

    4. XM_054370059.1XP_054226034.1  MOB kinase activator 2 isoform X12

    5. XM_054370060.1XP_054226035.1  MOB kinase activator 2 isoform X13

    6. XM_054370057.1XP_054226032.1  MOB kinase activator 2 isoform X10