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    DUSP8 dual specificity phosphatase 8 [ Homo sapiens (human) ]

    Gene ID: 1850, updated on 9-Dec-2024

    Summary

    Official Symbol
    DUSP8provided by HGNC
    Official Full Name
    dual specificity phosphatase 8provided by HGNC
    Primary source
    HGNC:HGNC:3074
    See related
    Ensembl:ENSG00000184545 MIM:602038; AllianceGenome:HGNC:3074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HB5; HVH8; HVH-5; C11orf81
    Summary
    The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in brain (RPKM 9.1), colon (RPKM 3.4) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DUSP8 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1554051..1572848, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1635383..1654159, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1575281..1593501, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MOB kinase activator 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1520757-1521279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1528327-1529160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1529995-1530826 Neighboring gene uncharacterized LOC124902607 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1534293-1534794 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1534795-1535294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1541250-1541750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1541751-1542251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4289 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1547587-1548086 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:1553250-1553750 Neighboring gene uncharacterized LOC124902608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1576597-1577394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1578991-1579788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1580587-1581382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1588223-1589161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1589162-1590100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1590101-1591039 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1592555-1593102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1593651-1594196 Neighboring gene KRTAP5-1/KRTAP5-2 antisense RNA 1 Neighboring gene keratin associated protein 5-1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1617579-1618152 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1618727-1619300 Neighboring gene keratin associated protein 5-2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ42476, FLJ42958

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase tyrosine/serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dual specificity protein phosphatase 8
    Names
    H1 phosphatase, vaccinia virus homolog
    dual specificity protein phosphatase hVH-5
    serine/threonine specific protein phosphatase
    NP_004411.2
    XP_011518234.1
    XP_011518235.1
    XP_047282469.1
    XP_054184836.1
    XP_054184837.1
    XP_054184838.1
    XP_054185959.1
    XP_054185960.1
    XP_054185961.1
    XP_054189085.1
    XP_054189086.1
    XP_054189087.1
    XP_054223912.1
    XP_054223913.1
    XP_054223914.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004420.3NP_004411.2  dual specificity protein phosphatase 8

      See identical proteins and their annotated locations for NP_004411.2

      Status: REVIEWED

      Source sequence(s)
      AK124467, AP006285, BC045110, BU740880, U27193
      Consensus CDS
      CCDS7724.1
      UniProtKB/Swiss-Prot
      Q13202, Q86SS8
      Related
      ENSP00000380530.3, ENST00000397374.8
      Conserved Domains (2) summary
      cd00127
      Location:160297
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:10137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      1554051..1572848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011519933.3XP_011518235.1  dual specificity protein phosphatase 8 isoform X1

      See identical proteins and their annotated locations for XP_011518235.1

      UniProtKB/Swiss-Prot
      Q13202, Q86SS8
      Related
      ENSP00000329539.4, ENST00000331588.4
      Conserved Domains (2) summary
      cd00127
      Location:160297
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:10137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    2. XM_047426513.1XP_047282469.1  dual specificity protein phosphatase 8 isoform X2

    3. XM_011519932.3XP_011518234.1  dual specificity protein phosphatase 8 isoform X1

      See identical proteins and their annotated locations for XP_011518234.1

      UniProtKB/Swiss-Prot
      Q13202, Q86SS8
      Conserved Domains (2) summary
      cd00127
      Location:160297
      DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
      cd01446
      Location:10137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791792.1 Reference GRCh38.p14 PATCHES

      Range
      294027..312824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333111.1XP_054189086.1  dual specificity protein phosphatase 8 isoform X1

      UniProtKB/Swiss-Prot
      Q13202, Q86SS8
    2. XM_054333112.1XP_054189087.1  dual specificity protein phosphatase 8 isoform X2

    3. XM_054333110.1XP_054189085.1  dual specificity protein phosphatase 8 isoform X1

      UniProtKB/Swiss-Prot
      Q13202, Q86SS8

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187584.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      36288..55085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328862.1XP_054184837.1  dual specificity protein phosphatase 8 isoform X1

      UniProtKB/Swiss-Prot
      Q13202, Q86SS8
    2. XM_054328863.1XP_054184838.1  dual specificity protein phosphatase 8 isoform X2

    3. XM_054328861.1XP_054184836.1  dual specificity protein phosphatase 8 isoform X1

      UniProtKB/Swiss-Prot
      Q13202, Q86SS8

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187657.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      30578..49375 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329985.1XP_054185960.1  dual specificity protein phosphatase 8 isoform X1

      UniProtKB/Swiss-Prot
      Q13202, Q86SS8
    2. XM_054329986.1XP_054185961.1  dual specificity protein phosphatase 8 isoform X2

    3. XM_054329984.1XP_054185959.1  dual specificity protein phosphatase 8 isoform X1

      UniProtKB/Swiss-Prot
      Q13202, Q86SS8

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      1635383..1654159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367938.1XP_054223913.1  dual specificity protein phosphatase 8 isoform X1

      UniProtKB/Swiss-Prot
      Q13202, Q86SS8
    2. XM_054367939.1XP_054223914.1  dual specificity protein phosphatase 8 isoform X2

    3. XM_054367937.1XP_054223912.1  dual specificity protein phosphatase 8 isoform X1

      UniProtKB/Swiss-Prot
      Q13202, Q86SS8