ctps-1 CTP synthase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ctps-1
Official Full Name: CTP synthase
Primary source: WormBase:WBGene00012316
Locus tag: CELE_W06H3.3
See related: AllianceGenome:WB:WBGene00012316
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable CTP synthase activity and identical protein binding activity. Predicted to be involved in CTP biosynthetic process and pyrimidine nucleobase biosynthetic process. Predicted to be active in cytoophidium and cytoplasm. Is expressed in germ line and intestine. Human ortholog(s) of this gene implicated in immunodeficiency 24. Orthologous to human CTPS1 (CTP synthase 1) and CTPS2 (CTP synthase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ctps-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (16794908..16802758)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

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Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W06H3.2 (e-PCR)
- UniSTS:312813

W06H3.3 (e-PCR)
- UniSTS:312814

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables CTP synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables CTP synthase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in CTP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoophidium	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CTP synthase

NP_001366646.1

Confirmed by transcript evidence

NP_001391182.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

16794908..16802758

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001404190.1 → NP_001391182.1 CTP synthase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A8S4QD99
NM_001380849.2 → NP_001366646.1 CTP synthase [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G5EC98

Conserved Domains (1) summary

PLN02327
Location:8 → 618

PLN02327; CTP synthase