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    plc-3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3 [ Caenorhabditis elegans ]

    Gene ID: 174586, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plc-3
    Official Full Name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
    Primary source
    WormBase:WBGene00004038
    Locus tag
    CELE_T01E8.3
    See related
    AllianceGenome:WB:WBGene00004038
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Involved in sleep. Predicted to be active in ruffle membrane. Is expressed in ALA; gonad; intestine; and non-striated muscle. Human ortholog(s) of this gene implicated in familial cold autoinflammatory syndrome 3; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to several human genes including PLCG2 (phospholipase C gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See plc-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    13
    Sequence:
    Chromosome: II; NC_003280.10 (10222877..10229440)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Regulator of fusion ref-1 Neighboring gene Serpentine Receptor, class H Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene UBX domain-containing protein 5 Neighboring gene F-box/WD repeat-containing protein mec-15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inositol 1,4,5-trisphosphate signalling regulates the avoidance response to nose touch in Caenorhabditis elegans. Walker DS, et al. PLoS Genet, 2009 Sep. PMID 19730689, Free PMC Article
    2. High-throughput transcriptome sequencing reveals extremely high doses of ionizing radiation-response genes in Caenorhabditis elegans. Xu Y, et al. Toxicol Res (Camb), 2019 Sep 1. PMID 31588352, Free PMC Article
    3. Phosphatidylinositol 4,5-bisphosphate and loss of PLCgamma activity inhibit TRPM channels required for oscillatory Ca2+ signaling. Xing J, et al. Am J Physiol Cell Physiol, 2010 Feb. PMID 19923421, Free PMC Article
    4. Phospholipase C-epsilon regulates epidermal morphogenesis in Caenorhabditis elegans. Vázquez-Manrique RP, et al. PLoS Genet, 2008 Mar 28. PMID 18369461, Free PMC Article
    5. DEC-7/SUSD2, a sushi domain-containing protein, regulates an ultradian behavior mediated by intestinal epithelial Ca(2+) oscillations in Caenorhabditis elegans. Laboy JT, et al. Am J Physiol Cell Physiol, 2023 May 1. PMID 37067458, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of epithelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3
    NP_496205.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      10222877..10229440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063804.5 → NP_496205.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma plc-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496205.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22070
      Conserved Domains (8) summary
      smart00149
      Location:983 → 1092
      PLCYc; Phospholipase C, catalytic domain (part); domain Y
      cd00275
      Location:1110 → 1222
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08592
      Location:351 → 494
      PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
      cd09932
      Location:710 → 813
      SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
      cd10341
      Location:600 → 696
      SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
      smart00326
      Location:833 → 886
      SH3; Src homology 3 domains
      pfam09279
      Location:278 → 350
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl17171
      Location:74 → 191
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22070.2

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