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    qui-1 Protein qui-1 [ Caenorhabditis elegans ]

    Gene ID: 178326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    qui-1
    Official Full Name
    Protein qui-1
    Primary source
    WormBase:WBGene00004265
    Locus tag
    CELE_Y45F10B.10
    See related
    AllianceGenome:WB:WBGene00004265
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in response to alkaloid. Located in several cellular components, including axon; dendrite; and neuronal cell body. Is expressed in ganglia; head neurons; and nerve ring. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See qui-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    19
    Sequence:
    Chromosome: IV; NC_003282.8 (13561861..13574440)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Chitin-binding type-2 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class D (Delta) Neighboring gene RING-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans. Hilliard MA, et al. EMBO J, 2004 Mar 10. PMID 14988722, Free PMC Article
    2. Avoidance behavior and experience-dependent tolerance in response to bitter compounds in Caenorhabditis elegans. Ishikawa S, et al. Biosci Biotechnol Biochem, 2023 Feb 24. PMID 36494200
    3. A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans. Neal SJ, et al. G3 (Bethesda), 2016 May 3. PMID 26976437, Free PMC Article
    4. Impairing one sensory modality enhances another by reconfiguring peptidergic signalling in Caenorhabditis elegans. Valperga G, et al. Elife, 2022 Feb 24. PMID 35201977, Free PMC Article
    5. From Odors to Behaviors in Caenorhabditis elegans. Menini A, et al. , 2010. PMID 21882435

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. qui-1 codes for a novel protein with WD-40 domains and which is expressed in the avoidance sensory neurons
      Title: Worms taste bitter: ASH neurons, QUI-1, GPA-3 and ODR-3 mediate quinine avoidance in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to alkaloid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Protein qui-1
    NP_001263809.1
    • Confirmed by transcript evidence
    NP_001294084.1
    • Confirmed by transcript evidence
    NP_502613.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      13561861..13574440
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070212.4 → NP_502613.2  Protein qui-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_502613.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      I2HAI7, N1NTL8, O62471
      Conserved Domains (2) summary
      cd00200
      Location:903 → 1192
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:870 → 909
      7WD40; WD40 repeat [structural motif]

    2. NM_001276880.2 → NP_001263809.1  Protein qui-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      I2HAI7

    3. NM_001307155.3 → NP_001294084.1  Protein qui-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294084.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      N1NTL8
      Conserved Domains (2) summary
      cd00200
      Location:638 → 927
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:605 → 644
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O62471.2

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