U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    gcn-2 Eukaryotic translation initiation factor 2-alpha kinase gcn-2 [ Caenorhabditis elegans ]

    Gene ID: 174953, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    gcn-2
    Official Full Name
    Eukaryotic translation initiation factor 2-alpha kinase gcn-2
    Primary source
    WormBase:WBGene00013591
    Locus tag
    CELE_Y81G3A.3
    See related
    AllianceGenome:WB:WBGene00013591
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable eukaryotic translation initiation factor 2alpha kinase activity. Involved in several processes, including determination of adult lifespan; mitochondrial unfolded protein response; and positive regulation of protein modification process. Acts upstream of with a positive effect on positive regulation of gene expression. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in pulmonary venoocclusive disease 2. Orthologous to human EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See gcn-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (13084164..13091501)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Secreted protein Neighboring gene DUF3444 domain-containing protein Neighboring gene DUF19 domain-containing protein Neighboring gene Collagen triple helix repeat protein;Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene RICTOR_N domain-containing protein;Rapamycin-insensitive companion of mTOR domain-containing protein Neighboring gene protein of unknown function DB domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The integrated stress response protects against ER stress but is not required for altered translation and lifespan from dietary restriction in Caenorhabditis elegans. Ma Z, et al. Front Cell Dev Biol, 2023. PMID 38161330, Free PMC Article
    2. Changes in translation rate modulate stress-induced damage of diverse proteins. Kim H, et al. Am J Physiol Cell Physiol, 2013 Dec 15. PMID 24153430, Free PMC Article
    3. V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans. Li TY, et al. J Cell Biol, 2023 Jan 2. PMID 36314986, Free PMC Article
    4. IMPACT is a GCN2 inhibitor that limits lifespan in Caenorhabditis elegans. Ferraz RC, et al. BMC Biol, 2016 Oct 7. PMID 27717342, Free PMC Article
    5. Mitochondrial Sulfide Quinone Oxidoreductase Prevents Activation of the Unfolded Protein Response in Hydrogen Sulfide. Horsman JW, et al. J Biol Chem, 2016 Mar 4. PMID 26677221, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling
      Title: GCN-2 dependent inhibition of protein synthesis activates osmosensitive gene transcription via WNK and Ste20 kinase signaling.
    2. The experiments described here implicate the eIF2alpha kinase GCN-2 in the maintenance of mitochondrial function and protein homeostasis.
      Title: Protective coupling of mitochondrial function and protein synthesis via the eIF2α kinase GCN-2.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in TOR signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of translational initiation in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_positive_effect positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein oxidation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of brood size IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to UV IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to sodium arsenite IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stress granule assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Eukaryotic translation initiation factor 2-alpha kinase gcn-2
    NP_001366669.1
    • Confirmed by transcript evidence
    NP_001367229.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13084164..13091501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381637.2 → NP_001366669.1  Eukaryotic translation initiation factor 2-alpha kinase gcn-2 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (4) summary
      smart00591
      Location:23 → 138
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      COG3705
      Location:1141 → 1397
      HisZ; ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism]
      cl00268
      Location:1106 → 1227
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
      cl21453
      Location:776 → 997
      PKc_like; Protein Kinases, catalytic domain

    2. NM_001381636.1 → NP_001367229.1  Eukaryotic translation initiation factor 2-alpha kinase gcn-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D0Z5N4, Q9XVY4
      Conserved Domains (4) summary
      smart00591
      Location:23 → 138
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      COG3705
      Location:1141 → 1397
      HisZ; ATP phosphoribosyltransferase regulatory subunit HisZ [Amino acid transport and metabolism]
      cl00268
      Location:1106 → 1227
      class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...
      cl21453
      Location:776 → 997
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D0Z5N4.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools