ccb-1 Guanylate kinase/L-type calcium channel beta subunit domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ccb-1
Official Full Name: Guanylate kinase/L-type calcium channel beta subunit domain-containing protein
Primary source: WormBase:WBGene00000368
Locus tag: CELE_T28F2.5
See related: AllianceGenome:WB:WBGene00000368
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable high voltage-gated calcium channel activity. Involved in positive regulation of locomotion; regulation of calcium ion transport; and striated muscle contraction involved in embryonic body morphogenesis. Located in presynaptic active zone. Is expressed in muscle cell; neurons; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in Brugada syndrome 4; episodic ataxia (multiple); hypertension; idiopathic generalized epilepsy 9; and intrinsic cardiomyopathy (multiple). Orthologous to several human genes including CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ccb-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (3641651..3647082, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EGL-19, UNC-36, and CCB-1 underlie voltage-dependent calcium currents in C. elegans striated muscle.
Title: The alpha1 subunit EGL-19, the alpha2/delta subunit UNC-36, and the beta subunit CCB-1 underlie voltage-dependent calcium currents in Caenorhabditis elegans striated muscle.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T28F2.5 (e-PCR)
- UniSTS:315126

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables high voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in striated muscle contraction involved in embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Guanylate kinase/L-type calcium channel beta subunit domain-containing protein

NP_491193.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3641651..3647082 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058792.6 → NP_491193.2 Guanylate kinase/L-type calcium channel beta subunit domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491193.2

Status: REVIEWED

UniProtKB/TrEMBL

O01661

Conserved Domains (3) summary

cd11863
Location:51 → 112

SH3_CACNB; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta

pfam00625
Location:198 → 380

Guanylate_kin; Guanylate kinase

pfam12052
Location:7 → 47

VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal