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    gpx-2 Glutathione peroxidase;Glutathione peroxidase 2 [ Caenorhabditis elegans ]

    Gene ID: 187630, updated on 9-Dec-2024

    Summary

    Official Symbol
    gpx-2
    Official Full Name
    Glutathione peroxidase;Glutathione peroxidase 2
    Primary source
    WormBase:WBGene00011045
    Locus tag
    CELE_R05H10.5
    See related
    AllianceGenome:WB:WBGene00011045
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable peroxidase activity. Predicted to be involved in cellular oxidant detoxification and response to oxidative stress. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See gpx-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (14866766..14869671)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene N-acetyltransferase domain-containing protein Neighboring gene RRM domain-containing protein Neighboring gene Dot/Icm T4SS effector;Non-specific serine/threonine protein kinase Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to chemical IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    Glutathione peroxidase;Glutathione peroxidase 2
    NP_001366911.1
    • Confirmed by transcript evidence
    NP_001368229.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14866766..14869671
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001381665.2NP_001368229.1  Glutathione peroxidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PB05
      Conserved Domains (1) summary
      cd00340
      Location:19171
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...
    2. NM_001381666.1NP_001366911.1  Glutathione peroxidase 2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62327
      Conserved Domains (1) summary
      cd00340
      Location:3155
      GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...