dmsr-1 G-protein coupled receptor dmsr-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dmsr-1
Official Full Name: G-protein coupled receptor dmsr-1
Primary source: WormBase:WBGene00010191
Locus tag: CELE_F57B7.1
See related: AllianceGenome:WB:WBGene00010191
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables neuropeptide receptor activity. Involved in regulation of cellular response to heat and regulation of circadian sleep/wake cycle, sleep. Located in neuronal cell body membrane. Is expressed in head neurons and tail neurons. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dmsr-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (11438764..11441638)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DMSR-1 is activated by FLP-13 peptides in cell culture, is required for stress-induced sleep in vivo, is expressed non-synaptically in several wake-promoting neurons, and likely couples to a Gi/o heterotrimeric G-protein.
Title: The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F57B7.1 (e-PCR)
- UniSTS:311900

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled peptide receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of cellular response to heat	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptor dmsr-1

NP_741629.1

Confirmed by transcript evidence

NP_741630.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11438764..11441638

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171542.7 → NP_741630.1 G-protein coupled receptor dmsr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741630.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQ19

Conserved Domains (1) summary

cd14978
Location:32 → 374

7tmA_FMRFamide_R-like; FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_171541.7 → NP_741629.1 G-protein coupled receptor dmsr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741629.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q20929, Q8MQ19

Conserved Domains (1) summary

cd14978
Location:32 → 374

7tmA_FMRFamide_R-like; FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors