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    dgk-3 putative diacylglycerol kinase 3 [ Caenorhabditis elegans ]

    Gene ID: 186262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dgk-3
    Official Full Name
    putative diacylglycerol kinase 3
    Primary source
    WormBase:WBGene00000960
    Locus tag
    CELE_F54G8.2
    See related
    AllianceGenome:WB:WBGene00000960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP-dependent diacylglycerol kinase activity. Involved in olfactory behavior; regulation of long-term neuronal synaptic plasticity; and thermotaxis. Predicted to be active in plasma membrane. Is expressed in head; intestine; nervous system; and pharyngeal lumen. Orthologous to human DGKA (diacylglycerol kinase alpha); DGKB (diacylglycerol kinase beta); and DGKG (diacylglycerol kinase gamma). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dgk-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    15
    Sequence:
    Chromosome: III; NC_003281.10 (9163068..9168196)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Patched-related protein 9 Neighboring gene ncRNA Neighboring gene Integrin alpha ina-1 Neighboring gene pseudo Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A diacylglycerol kinase modulates long-term thermotactic behavioral plasticity in C. elegans. Biron D, et al. Nat Neurosci, 2006 Dec. PMID 17086178
    2. BRCA1-BARD1 Regulates Axon Regeneration in Concert with the Gqα-DAG Signaling Network. Sakai Y, et al. J Neurosci, 2021 Mar 31. PMID 33593852, Free PMC Article
    3. PKC-2 phosphorylation of UNC-18 Ser322 in AFD neurons regulates temperature dependency of locomotion. Edwards MR, et al. J Neurosci, 2012 May 16. PMID 22593072, Free PMC Article
    4. Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans. Matsuki M, et al. Proc Natl Acad Sci U S A, 2006 Jan 24. PMID 16418272, Free PMC Article
    5. Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma. Espelt MV, et al. J Gen Physiol, 2005 Oct. PMID 16186564, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in olfactory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of long-term neuronal synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thermotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative diacylglycerol kinase 3
    NP_499031.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      9163068..9168196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066630.4 → NP_499031.3  putative diacylglycerol kinase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499031.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03603
      Conserved Domains (7) summary
      smart00045
      Location:578 → 753
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:429 → 551
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:429 → 763
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00051
      Location:174 → 243
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:266 → 317
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:178 → 239
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:3 → 168
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03603.3

    Gene LinkOut

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