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    ant-1.3 ADP/ATP translocase [ Caenorhabditis elegans ]

    Gene ID: 186855, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ant-1.3
    Official Full Name
    ADP/ATP translocase
    Primary source
    WormBase:WBGene00010485
    Locus tag
    CELE_K01H12.2
    See related
    AllianceGenome:WB:WBGene00010485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable adenine nucleotide transmembrane transporter activity. Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway. Predicted to be located in mitochondrial inner membrane. Is expressed in VA11 and intestine. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to several human genes including SLC25A5 (solute carrier family 25 member 5) and SLC25A6 (solute carrier family 25 member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ant-1.3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    3
    Sequence:
    Chromosome: IV; NC_003282.8 (9708168..9709305, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene DDB1- and CUL4-associated factor homolog 1 Neighboring gene ncRNA Neighboring gene DPH-type MB domain-containing protein;Diphthamide biosynthesis protein 3 Neighboring gene Nuclear receptor domain-containing protein Neighboring gene Breast cancer type 2 susceptibility protein homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential expression pattern of the four mitochondrial adenine nucleotide transporter ant genes and their roles during the development of Caenorhabditis elegans. Farina F, et al. Dev Dyn, 2008 Jun. PMID 18498090
    2. Adenine nucleotide translocator cooperates with core cell death machinery to promote apoptosis in Caenorhabditis elegans. Shen Q, et al. Mol Cell Biol, 2009 Jul. PMID 19414600, Free PMC Article
    3. Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension. Zhou B, et al. Cell, 2019 Apr 4. PMID 30929899, Free PMC Article
    4. ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1. Statzer C, et al. Nat Commun, 2022 Feb 18. PMID 35181679, Free PMC Article
    5. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP:ADP antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenine nucleotide transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial ADP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial ATP transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ADP/ATP translocase
    NP_501727.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      9708168..9709305 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069326.5 → NP_501727.1  ADP/ATP translocase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501727.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EFW8
      Conserved Domains (2) summary
      PTZ00169
      Location:25 → 313
      PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
      pfam00153
      Location:21 → 120
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein
    Heading Accession and Version

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