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    trm-2A RRM domain-containing protein;tRNA (uracil(54)-C(5))-methyltransferase [ Caenorhabditis elegans ]

    Gene ID: 186775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    trm-2A
    Official Full Name
    RRM domain-containing protein;tRNA (uracil(54)-C(5))-methyltransferase
    Primary source
    WormBase:WBGene00019241
    Locus tag
    CELE_H24K24.4
    See related
    AllianceGenome:WB:WBGene00019241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA binding activity and RNA methyltransferase activity. Predicted to be involved in RNA processing and methylation. Used to study chromosome 22q11.2 deletion syndrome, distal. Orthologous to several human genes including TRMT2A (tRNA methyltransferase 2 homolog A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See trm-2A in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (904963..911593)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Zinc metalloproteinase nas-32 Neighboring gene Flavin-containing monooxygenase Neighboring gene Alcohol dehydrogenase class-3 Neighboring gene DUF2428 domain-containing protein;Leucine-rich repeat-containing protein 29;Protein NLRC3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A nematode model to evaluate microdeletion phenotype expression. Antkowiak KR, et al. G3 (Bethesda), 2024 Feb 7. PMID 37956108, Free PMC Article
    2. Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation. Gomes JE, et al. J Cell Biol, 2013 Aug 5. PMID 23918937, Free PMC Article
    3. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RRM domain-containing protein;tRNA (uracil(54)-C(5))-methyltransferase
    NP_001300128.1
    • Confirmed by transcript evidence
    NP_001300129.1
    • Confirmed by transcript evidence
    NP_001300130.1
    • Confirmed by transcript evidence
    NP_001300131.1
    • Confirmed by transcript evidence
    NP_503353.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      904963..911593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070952.6 → NP_503353.2  tRNA (uracil(54)-C(5))-methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503353.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N5L0
      Conserved Domains (3) summary
      TIGR02927
      Location:374 → 437
      SucB_Actino; 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase
      COG2265
      Location:128 → 596
      TrmA; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]
      cd12439
      Location:25 → 100
      RRM_TRMT2A; RNA recognition motif in tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) and similar proteins

    2. NM_001313199.3 → NP_001300128.1  tRNA (uracil(54)-C(5))-methyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AVN7
      Conserved Domains (2) summary
      TIGR02927
      Location:56 → 119
      SucB_Actino; 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase
      cl17173
      Location:4 → 278
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. NM_001313200.1 → NP_001300129.1  tRNA (uracil(54)-C(5))-methyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AXZ0
      Conserved Domains (1) summary
      cl17173
      Location:1 → 127
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. NM_001313201.2 → NP_001300130.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASM7
      Conserved Domains (1) summary
      cl17173
      Location:5 → 55
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. NM_001313202.1 → NP_001300131.1  RRM domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AUZ1
    Nucleotide Protein
    Heading Accession and Version

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