dab-1 PID domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dab-1
Official Full Name: PID domain-containing protein
Primary source: WormBase:WBGene00000894
Locus tag: CELE_M110.5
See related: AllianceGenome:WB:WBGene00000894
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables clathrin heavy chain binding activity and protein domain specific binding activity. Involved in several processes, including ecdysis, collagen and cuticulin-based cuticle; egg-laying behavior; and positive regulation of growth rate. Located in cell cortex; clathrin-coated pit; and cytoplasmic vesicle. Is expressed in several structures, including P3.p hermaphrodite; amphid sheath cell; anchor cell; oocyte; and vulval cell. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 37. Orthologous to several human genes including DAB1 (DAB adaptor protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dab-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 8

Sequence:: Chromosome: II; NC_003280.10 (8222386..8229152)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results show that ITSN-1 and Eps15 proteins function in the same genetic pathway, and appear to function synergistically with the clathrin-coat-associated sorting protein, Dab-1, for viability.
Title: ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1.
study shows DAB-1 is essential for uptake of yolk protein by developing oocytes & for localisation of RME-2; DAB-1 is required for endocytosis of molecules from the pseudocoelomic fluid by the coelomocytes & is expressed in epithelial tissues
Title: C. elegans Disabled is required for cell-type specific endocytosis and is essential in animals lacking the AP-3 adaptor complex.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M110.5 (e-PCR)
- UniSTS:306365

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables clathrin heavy chain binding	IDA Inferred from Direct Assay more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in ecdysis, collagen and cuticulin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi-associated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PID domain-containing protein

NP_001122626.2

Confirmed by transcript evidence

NP_001360462.1

Confirmed by transcript evidence

NP_001360463.1

Partially confirmed by transcript evidence

NP_001360464.1

Partially confirmed by transcript evidence

NP_001360465.1

Partially confirmed by transcript evidence

NP_001370068.1

Confirmed by transcript evidence

NP_495730.3

Confirmed by transcript evidence

NP_495732.3

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

8222386..8229152

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063329.8 → NP_495730.3 PID domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495730.3

Status: REVIEWED

UniProtKB/TrEMBL

Q9U3A5, Q9U3A6, Q9U3A7

Conserved Domains (1) summary

cd01215
Location:37 → 184

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
NM_001129154.6 → NP_001122626.2 PID domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001122626.2

Status: REVIEWED

UniProtKB/TrEMBL

A5JYR4

Conserved Domains (1) summary

cd01215
Location:37 → 184

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
NM_001373756.3 → NP_001360462.1 PID domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WXX8

Conserved Domains (1) summary

cd01215
Location:37 → 184

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
NM_001383903.2 → NP_001370068.1 PID domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q8I4H0

Conserved Domains (1) summary

cd01215
Location:37 → 184

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
NM_063331.6 → NP_495732.3 PID domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495732.3

Status: REVIEWED

UniProtKB/TrEMBL

Q8I4G9

Conserved Domains (1) summary

cd01215
Location:21 → 168

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
NM_001373760.3 → NP_001360465.1 PID domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WV70

Conserved Domains (1) summary

cd01215
Location:21 → 168

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
NM_001373758.3 → NP_001360464.1 PID domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WV45

Conserved Domains (1) summary

cd01215
Location:21 → 168

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain
NM_001373759.3 → NP_001360463.1 PID domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WUH7

Conserved Domains (1) summary

cd01215
Location:21 → 168

PTB_Dab; Disabled (Dab) Phosphotyrosine-binding domain