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    ehbp-1 EH domain-binding protein 1 [ Caenorhabditis elegans ]

    Gene ID: 179343, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ehbp-1
    Official Full Name
    EH domain-binding protein 1
    Primary source
    WormBase:WBGene00009098
    Locus tag
    CELE_F25B3.1
    See related
    AllianceGenome:WB:WBGene00009098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables small GTPase binding activity. Involved in endocytic recycling; protein secretion; and receptor recycling. Located in early endosome membrane and recycling endosome membrane. Is expressed in several structures, including hermaphrodite gonad; intestine; nerve ring; pharynx; and seam cell. Orthologous to several human genes including EHBP1 (EH domain binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ehbp-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    14
    Sequence:
    Chromosome: V; NC_003283.11 (9550644..9556032)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ras guanyl-releasing protein 3 Neighboring gene ncRNA Neighboring gene Serine/threonine-protein phosphatase Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. UPR(ER) promotes lipophagy independent of chaperones to extend life span. Daniele JR, et al. Sci Adv, 2020 Jan. PMID 31911951, Free PMC Article
    2. RAB-10 Promotes EHBP-1 Bridging of Filamentous Actin and Tubular Recycling Endosomes. Wang P, et al. PLoS Genet, 2016 Jun. PMID 27272733, Free PMC Article
    3. An EHBP-1-SID-3-DYN-1 axis promotes membranous tubule fission during endocytic recycling. Gao J, et al. PLoS Genet, 2020 May. PMID 32384077, Free PMC Article
    4. RAB-10-GTPase-mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate. Shi A, et al. Proc Natl Acad Sci U S A, 2012 Aug 28. PMID 22869721, Free PMC Article
    5. WTS-1/LATS regulates endocytic recycling by restraining F-actin assembly in a synergistic manner. Zhang H, et al. J Cell Sci, 2021 Dec 15. PMID 34817059

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endocytic recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor recycling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    EH domain-binding protein 1
    NP_505468.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      9550644..9556032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073067.5 → NP_505468.1  EH domain-binding protein 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505468.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECW3
      Conserved Domains (3) summary
      cd00014
      Location:335 → 437
      CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
      pfam10358
      Location:12 → 166
      NT-C2; N-terminal C2 in EEIG1 and EHBP1 proteins
      pfam12130
      Location:737 → 866
      DUF3585; Protein of unknown function (DUF3585)
    Nucleotide Protein
    Heading Accession and Version

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