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    flp-10 FMRF-Like Peptide [ Caenorhabditis elegans ]

    Gene ID: 177574, updated on 9-Dec-2024

    Summary

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    Official Symbol
    flp-10
    Official Full Name
    FMRF-Like Peptide
    Primary source
    WormBase:WBGene00001453
    Locus tag
    CELE_T06C10.4
    See related
    AllianceGenome:WB:WBGene00001453
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in negative regulation of egg-laying behavior; negative regulation of turning behavior involved in mating; and thigmotaxis. Is expressed in nerve ring; neurons; and vulD. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See flp-10 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_003282.8 (7868907..7870081)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MADF domain-containing protein;WH2 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tyrosine-protein kinase Neighboring gene Tyrosine-protein kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FMRFamide-related peptides (FaRPs) in nematodes: occurrence and neuromuscular physiology. Maule AG, et al. Parasitology, 1996. PMID 9051931
    2. A competition mechanism for a homeotic neuron identity transformation in C. elegans. Gordon PM, et al. Dev Cell, 2015 Jul 27. PMID 26096732, Free PMC Article
    3. FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans. Ringstad N, et al. Nat Neurosci, 2008 Oct. PMID 18806786, Free PMC Article
    4. FMRFamide-like peptides expand the behavioral repertoire of a densely connected nervous system. Lee JS, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29167374, Free PMC Article
    5. Functional characterization of the putative orphan neuropeptide G-protein coupled receptor C26F1.6 in Caenorhabditis elegans. Mertens I, et al. FEBS Lett, 2004 Aug 27. PMID 15327975

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. flp-10 is required for the sensory transduction involved in male turning behavior.
      Title: FMRFamide-like neuropeptides and mechanosensory touch receptor neurons regulate male sexual turning behavior in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in negative regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of turning behavior involved in mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thigmotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    FMRF-Like Peptide
    NP_501306.1
    • Product from WormBase gene class flp;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7868907..7870081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068905.6 → NP_501306.1  FMRF-Like Peptide [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501306.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF22
    Nucleotide Protein
    Heading Accession and Version

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