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    dhhc-14 Palmitoyltransferase [ Caenorhabditis elegans ]

    Gene ID: 181109, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dhhc-14
    Official Full Name
    Palmitoyltransferase
    Primary source
    WormBase:WBGene00044071
    Locus tag
    CELE_D2021.2
    See related
    AllianceGenome:WB:WBGene00044071
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in protein targeting to membrane. Predicted to be located in Golgi apparatus and endoplasmic reticulum membrane. Predicted to be active in Golgi membrane. Is expressed in body wall musculature and neurons. Orthologous to human ZDHHC13 (zinc finger DHHC-type palmitoyltransferase 13) and ZDHHC17 (zinc finger DHHC-type palmitoyltransferase 17). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dhhc-14 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    12
    Sequence:
    Chromosome: X; NC_003284.9 (8552277..8556360)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Acyl-CoA thioesterase-like C-terminal domain-containing protein;HotDog ACOT-type domain-containing protein Neighboring gene JmjC domain-containing protein Neighboring gene JmjC domain-containing protein;Lysine-specific demethylase jmjd-3.1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A systematic analysis of protein palmitoylation in Caenorhabditis elegans. Edmonds MJ, et al. BMC Genomics, 2014 Oct 2. PMID 25277130, Free PMC Article
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Palmitoyltransferase
    NP_001024514.2
    • Confirmed by transcript evidence
    NP_001367419.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8552277..8556360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029343.4 → NP_001024514.2  Palmitoyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024514.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KYE9
      Conserved Domains (5) summary
      COG1989
      Location:261 → 367
      PulO; Prepilin signal peptidase PulO (type II secretory pathway) or related peptidase [Cell motility, Intracellular trafficking, secretion, and vesicular transport]
      cd00204
      Location:19 → 143
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01529
      Location:394 → 521
      zf-DHHC; DHHC palmitoyltransferase
      pfam12796
      Location:30 → 120
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:55 → 87
      ANK; ANK repeat [structural motif]

    2. NM_001381041.1 → NP_001367419.1  Palmitoyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7Z127
      Conserved Domains (1) summary
      pfam01529
      Location:43 → 170
      DHHC; DHHC palmitoyltransferase
    Nucleotide Protein
    Heading Accession and Version

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