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    • Showing Current items.

    mlc-5 Myosin-2 essential light chain [ Caenorhabditis elegans ]

    Gene ID: 176796, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mlc-5
    Official Full Name
    Myosin-2 essential light chain
    Primary source
    WormBase:WBGene00011734
    Locus tag
    CELE_T12D8.6
    See related
    AllianceGenome:WB:WBGene00011734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Involved in mitotic cytokinesis. Located in actin cytoskeleton. Is expressed in hypodermis; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital myopathy 14; familial atrial fibrillation; and hypertrophic cardiomyopathy 8. Orthologous to several human genes including MYL4 (myosin light chain 4); MYL6 (myosin light chain 6); and MYL6B (myosin light chain 6B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mlc-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (13623314..13624170)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Carbohydrate kinase FGGY N-terminal domain-containing protein Neighboring gene STI1 domain-containing protein Neighboring gene Protein PFC0760c-like Neighboring gene Transcription initiation factor TFIID subunit 9 Neighboring gene Secreted protein Neighboring gene Arrestin domain-containing protein 17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myosin II regulation during C. elegans embryonic elongation: LET-502/ROCK, MRCK-1 and PAK-1, three kinases with different roles. Gally C, et al. Development, 2009 Sep. PMID 19675126
    2. Anillin forms linear structures and facilitates furrow ingression after septin and formin depletion. Lebedev M, et al. Cell Rep, 2023 Sep 26. PMID 37665665, Free PMC Article
    3. Initial diameter of the polar body contractile ring is minimized by the centralspindlin complex. Fabritius AS, et al. Dev Biol, 2011 Nov 1. PMID 21889938, Free PMC Article
    4. DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans. Suen KM, et al. Nat Commun, 2020 Aug 25. PMID 32843637, Free PMC Article
    5. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Myosin-2 essential light chain
    NP_499813.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13623314..13624170
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067412.10 → NP_499813.1  Myosin-2 essential light chain [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499813.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XVI9
      Conserved Domains (3) summary
      PTZ00184
      Location:2 → 140
      PTZ00184; calmodulin; Provisional
      cd00051
      Location:79 → 140
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      cl08302
      Location:6 → 62
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XVI9.1

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