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    tbx-35 T-box transcription factor tbx-35 [ Caenorhabditis elegans ]

    Gene ID: 191239, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tbx-35
    Official Full Name
    T-box transcription factor tbx-35
    Primary source
    WormBase:WBGene00006554
    Locus tag
    CELE_ZK177.10
    See related
    AllianceGenome:WB:WBGene00006554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables sequence-specific DNA binding activity. Involved in cell fate specification; chordate pharyngeal muscle development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. Predicted to be active in nucleus. Is expressed in several structures, including MS; MSa; MSaa; MSap; and MSp. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tbx-35 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (5524101..5525397, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene NDK domain-containing protein Neighboring gene BHLH domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcript accumulation rates in the early Caenorhabditis elegans embryo. Sivaramakrishnan P, et al. Sci Adv, 2023 Aug 25. PMID 37611097, Free PMC Article
    2. Roles of the Wnt effector POP-1/TCF in the C. elegans endomesoderm specification gene network. Owraghi M, et al. Dev Biol, 2010 Apr 15. PMID 19818340, Free PMC Article
    3. Specification of the C. elegans MS blastomere by the T-box factor TBX-35. Broitman-Maduro G, et al. Development, 2006 Aug. PMID 16831832
    4. The conserved role and divergent regulation of foxa, a pan-eumetazoan developmental regulatory gene. de-Leon SB. Dev Biol, 2011 Sep 1. PMID 21130759, Free PMC Article
    5. The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have overlapping function in C. elegans mesoderm development. Broitman-Maduro G, et al. Development, 2009 Aug. PMID 19605496, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that TBX-35 and CEH-51 have overlapping function in MS blastomere lineage development.
      Title: The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have overlapping function in C. elegans mesoderm development.
    2. tbx-35 is repressed in a Wnt-dependent manner that does not require activity of TCF/POP-1, suggesting that an additional nuclear Wnt effector functions in E to repress MS development.
      Title: Specification of the C. elegans MS blastomere by the T-box factor TBX-35.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chordate pharyngeal muscle development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mesodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mesodermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in pharynx development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-box transcription factor tbx-35
    NP_495059.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5524101..5525397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062658.3 → NP_495059.2  T-box transcription factor tbx-35 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495059.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09376
      Conserved Domains (1) summary
      smart00425
      Location:23 → 215
      TBOX; Domain first found in the mice T locus (Brachyury) protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09376.2

    Gene LinkOut

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