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    tin-44 putative mitochondrial import inner membrane translocase subunit tin-44 [ Caenorhabditis elegans ]

    Gene ID: 172302, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tin-44
    Official Full Name
    putative mitochondrial import inner membrane translocase subunit tin-44
    Primary source
    WormBase:WBGene00020383
    Locus tag
    CELE_T09B4.9
    See related
    AllianceGenome:WB:WBGene00020383
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein-folding chaperone binding activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial inner membrane. Is expressed in intestine; nervous system; pharynx; reproductive system; and tail. Orthologous to human TIMM44 (translocase of inner mitochondrial membrane 44). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tin-44 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (6177934..6180840, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase CHIP Neighboring gene Torsin-1B Neighboring gene pre-microRNA mir-4916

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alignment of the genetic and physical maps in the dpy-5 bli-4 (I) region of C. elegans by the serial cosmid rescue of lethal mutations. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230901
    2. Genetic analysis of sterile mutants in the dpy-5 unc-13 (I) genomic region of Caenorhabditis elegans. McDowall JS, et al. Mol Gen Genet, 1997 Jun. PMID 9230900
    3. Allelic ratios and the mutational landscape reveal biologically significant heterozygous SNVs. Chu JS, et al. Genetics, 2012 Apr. PMID 22267497, Free PMC Article
    4. Mutational accessibility of essential genes on chromosome I(left) in Caenorhabditis elegans. Johnsen RC, et al. Mol Gen Genet, 2000 Mar. PMID 10778742
    5. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative mitochondrial import inner membrane translocase subunit tin-44
    NP_491780.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6177934..6180840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059379.5 → NP_491780.1  putative mitochondrial import inner membrane translocase subunit tin-44 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491780.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O02161
      Conserved Domains (4) summary
      TIGR00984
      Location:44 → 415
      3a0801s03tim44; mitochondrial import inner membrane, translocase subunit
      pfam04280
      Location:269 → 418
      Tim44; Tim44-like domain
      cl12013
      Location:37 → 111
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl23763
      Location:96 → 174
      MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O02161.1

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