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    mlp-1 LIM zinc-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mlp-1
    Official Full Name
    LIM zinc-binding domain-containing protein
    Primary source
    WormBase:WBGene00003375
    Locus tag
    CELE_T04C9.4
    See related
    AllianceGenome:WB:WBGene00003375
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Located in striated muscle dense body. Is expressed in several structures, including intestine; nervous system; non-striated muscle; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to several human genes including CSRP1 (cysteine and glycine rich protein 1); CSRP2 (cysteine and glycine rich protein 2); and CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mlp-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (5971527..5973665, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein dct-6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene FERM domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The LIM domain protein UNC-95 is required for the assembly of muscle attachment structures and is regulated by the RING finger protein RNF-5 in C. elegans. Broday L, et al. J Cell Biol, 2004 Jun 21. PMID 15210732, Free PMC Article
    2. The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification. Zhang C, et al. Curr Biol, 2012 May 22. PMID 22542102, Free PMC Article
    3. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
    4. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    LIM zinc-binding domain-containing protein
    NP_001263705.1
    • Confirmed by transcript evidence
    NP_001360006.1
    • Confirmed by transcript evidence
    NP_001367782.1
    • Confirmed by transcript evidence
    NP_498300.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5971527..5973665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276776.3 → NP_001263705.1  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001263705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      L8E6X8
      Conserved Domains (1) summary
      cd09404
      Location:10 → 63
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A

    2. NM_001372606.4 → NP_001360006.1  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GP94
      Conserved Domains (1) summary
      cd09404
      Location:10 → 63
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A

    3. NM_065899.8 → NP_498300.2  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498300.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2KZV8
      Conserved Domains (1) summary
      cd09404
      Location:10 → 63
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A

    4. NM_001379735.3 → NP_001367782.1  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9GP96
      Conserved Domains (1) summary
      cd09404
      Location:10 → 63
      LIM1_MLP84B_like; The LIM domain of Mlp84B and Mlp60A
    Nucleotide Protein
    Heading Accession and Version

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