cls-3 Protein CLASP-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cls-3
Official Full Name: Protein CLASP-3
Primary source: WormBase:WBGene00013847
Locus tag: CELE_ZC84.3
See related: AllianceGenome:WB:WBGene00013847
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable microtubule binding activity. Involved in astral microtubule organization and establishment of mitotic spindle localization. Predicted to be located in cytoplasm and microtubule. Predicted to be active in basal cortex; kinetochore; and microtubule cytoskeleton. Is expressed in neurons and pharyngeal gland cell. Orthologous to several human genes including CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cls-3 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 12

Sequence:: Chromosome: III; NC_003281.10 (9186558..9191109, complement)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that depletion of CLS-2 in combination with either CLS-1 or CLS-3 results in defects in nuclear rotation, maintenance of spindle length, and spindle displacement in the one-cell embryo.
Title: CLASPs function redundantly to regulate astral microtubules in the C. elegans embryo.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZC84.3 (e-PCR)
- UniSTS:306242

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in astral microtubule organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of mitotic spindle localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basal cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle microtubule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Protein CLASP-3

NP_001379049.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

9186558..9191109 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392172.1 → NP_001379049.1 Protein CLASP-3 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P91845, Q03609

Conserved Domains (1) summary

pfam12348
Location:50 → 255

CLASP_N; CLASP N terminal