U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    exc-9 LIM zinc-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177586, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    exc-9
    Official Full Name
    LIM zinc-binding domain-containing protein
    Primary source
    WormBase:WBGene00017644
    Locus tag
    CELE_F20D12.5
    See related
    AllianceGenome:WB:WBGene00017644
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable zinc ion binding activity. Involved in several processes, including body morphogenesis; morphogenesis of a polarized epithelium; and nematode male tail tip morphogenesis. Located in cytoplasm. Is expressed in several structures, including ALM; distal tip cell; excretory canal; lumbar ganglion; and nerve ring. Orthologous to human CRIP1 (cysteine rich protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See exc-9 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (7939812..7941019, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ion_trans domain-containing protein Neighboring gene ncRNA Neighboring gene Centromere/kinetochore protein zw10 homolog Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Terminal web and vesicle trafficking proteins mediate nematode single-cell tubulogenesis. Yang Z, et al. J Cell Biol, 2020 Nov 2. PMID 32860501, Free PMC Article
    2. Facilitation of Endosomal Recycling by an IRG Protein Homolog Maintains Apical Tubule Structure in Caenorhabditis elegans. Grussendorf KA, et al. Genetics, 2016 Aug. PMID 27334269, Free PMC Article
    3. A role for the C. elegans L1CAM homologue lad-1/sax-7 in maintaining tissue attachment. Wang X, et al. Dev Biol, 2005 Aug 15. PMID 16023097
    4. CRIP homologues maintain apical cytoskeleton to regulate tubule size in C. elegans. Tong X, et al. Dev Biol, 2008 May 1. PMID 18384766, Free PMC Article
    5. Cystic canal mutants in Caenorhabditis elegans are defective in the apical membrane domain of the renal (excretory) cell. Buechner M, et al. Dev Biol, 1999 Oct 1. PMID 10491271

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of a polarized epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nematode male tail tip morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of tube size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    LIM zinc-binding domain-containing protein
    NP_501326.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7939812..7941019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068925.6 → NP_501326.2  LIM zinc-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501326.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19641
      Conserved Domains (1) summary
      cd09401
      Location:4 → 58
      LIM_TLP_like; The LIM domains of thymus LIM protein (TLP)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools