pro-3 Protein SDA1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pro-3
Official Full Name: Protein SDA1 homolog
Primary source: WormBase:WBGene00012676
Locus tag: CELE_Y39B6A.14
See related: AllianceGenome:WB:WBGene00012676
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to be involved in ribosomal large subunit biogenesis and ribosomal large subunit export from nucleus. Predicted to be located in nucleus. Predicted to be active in nucleolus. Orthologous to human SDAD1 (SDA1 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pro-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 9

Sequence:: Chromosome: V; NC_003283.11 (19101347..19118412, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We report the characterization of two additional genes identified for their germline tumor phenotype, pro-2 and pro-3, and find that they encode orthologs of proteins involved in ribosome biogenesis in yeast (NOC2 and SDA1, respectively).
Title: Alterations in ribosome biogenesis cause specific defects in C. elegans hermaphrodite gonadogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y39B6B.a (e-PCR)
- UniSTS:323919

Y39B6B.s (e-PCR)
- UniSTS:324303

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in gonadal mesoderm development	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Protein SDA1 homolog

NP_001379304.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

19101347..19118412 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392694.1 → NP_001379304.1 Protein SDA1 homolog [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

A7UGI8, Q9NEU2, Q9NEV8

Conserved Domains (2) summary

pfam05285
Location:456 → 795

SDA1

pfam08158
Location:99 → 148

NUC130_3NT; NUC130/3NT domain