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    zhp-4 Zip homologous protein 4 [ Caenorhabditis elegans ]

    Gene ID: 3565475, updated on 9-Dec-2024

    Summary

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    Official Symbol
    zhp-4
    Official Full Name
    Zip homologous protein 4
    Primary source
    WormBase:WBGene00012678
    Locus tag
    CELE_Y39B6A.16
    See related
    AllianceGenome:WB:WBGene00012678
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable SUMO transferase activity. Predicted to be involved in homologous chromosome pairing at meiosis. Predicted to be located in chromosome. Predicted to be active in synaptonemal complex. Human ortholog(s) of this gene implicated in spermatogenic failure 62. Orthologous to human RNF212 (ring finger protein 212). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See zhp-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    5
    Sequence:
    Chromosome: V; NC_003283.11 (19099035..19101786, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene NR LBD domain-containing protein Neighboring gene pseudo Neighboring gene Protein SDA1 homolog Neighboring gene RsbRD_N domain-containing protein Neighboring gene ncRNA Neighboring gene BED-type domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans ZHP-4 is required at multiple distinct steps in the formation of crossovers and their transition to segregation competent chiasmata. Nguyen H, et al. PLoS Genet, 2018 Oct. PMID 30379819, Free PMC Article
    2. A compartmentalized signaling network mediates crossover control in meiosis. Zhang L, et al. Elife, 2018 Mar 9. PMID 29521627, Free PMC Article
    3. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables SUMO transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptonemal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptonemal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zip homologous protein 4
    NP_741682.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      19099035..19101786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171592.5 → NP_741682.1  Zip homologous protein 4 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741682.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MYP1
      Conserved Domains (1) summary
      pfam14634
      Location:5 → 51
      zf-RING_5; zinc-RING finger domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MYP1.1

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