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    brc-2 DNA repair protein brc-2 [ Caenorhabditis elegans ]

    Gene ID: 175962, updated on 9-Dec-2024

    Summary

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    Official Symbol
    brc-2
    Official Full Name
    DNA repair protein brc-2
    Primary source
    WormBase:WBGene00020316
    Locus tag
    CELE_T07E3.5
    See related
    AllianceGenome:WB:WBGene00020316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables single-stranded DNA binding activity. Involved in several processes, including DNA metabolic process; egg-laying behavior; and embryo development. Located in condensed nuclear chromosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See brc-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (6900568..6903106, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene BRCA1-associated RING domain protein 1 Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene DNA polymerase V Neighboring gene INSulin related Neighboring gene F-box domain-containing protein Neighboring gene DSBA-like thioredoxin domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Essential role of brc-2 in chromosome integrity of germ cells in C. elegans. Ko E, et al. Mol Cells, 2008 Dec 31. PMID 18779660
    2. Identification of Rad51 regulation by BRCA2 using Caenorhabditis elegans BRCA2 and bimolecular fluorescence complementation analysis. Min J, et al. Biochem Biophys Res Commun, 2007 Nov 3. PMID 17767921
    3. Stabilization of RAD-51-DNA filaments via an interaction domain in Caenorhabditis elegans BRCA2. Petalcorin MI, et al. Proc Natl Acad Sci U S A, 2007 May 15. PMID 17483448, Free PMC Article
    4. CeBRC-2 stimulates D-loop formation by RAD-51 and promotes DNA single-strand annealing. Petalcorin MI, et al. J Mol Biol, 2006 Aug 11. PMID 16843491
    5. Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins. Belan O, et al. Mol Cell, 2021 Mar 4. PMID 33421363, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins.
      Title: Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins.
    2. BRC-2-ALP-1 complex regulates axon regeneration.
      Title: The C. elegans BRCA2-ALP/Enigma Complex Regulates Axon Regeneration via a Rho GTPase-ROCK-MLC Phosphorylation Pathway.
    3. results suggest that brc-2 plays essential roles in chromosome integrity in early prophase, and therefore is crucial in meiotic progression and embryonic survival.
      Title: Essential role of brc-2 in chromosome integrity of germ cells in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA strand invasion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via single-strand annealing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic DNA recombinase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA repair protein brc-2
    NP_498502.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6900568..6903106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066101.8 → NP_498502.3  DNA repair protein brc-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498502.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EG86
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G5EG86.1

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