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    sul-3 Sulfatase N-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 183778, updated on 9-Dec-2024

    Summary

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    Official Symbol
    sul-3
    Official Full Name
    Sulfatase N-terminal domain-containing protein
    Primary source
    WormBase:WBGene00006310
    Locus tag
    CELE_C54D2.4
    See related
    AllianceGenome:WB:WBGene00006310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sulfuric ester hydrolase activity. Is expressed in body wall musculature; hypodermis; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to several human genes including ARSI (arylsulfatase family member I) and ARSJ (arylsulfatase family member J). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See sul-3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (7827085..7834217, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Elongation factor 1-alpha Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables sulfuric ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sulfatase N-terminal domain-containing protein
    NP_001360719.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      7827085..7834217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373376.2 → NP_001360719.1  Sulfatase N-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4V0IJ66
      Conserved Domains (1) summary
      cd16029
      Location:31 → 433
      4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B
    Nucleotide Protein
    Heading Accession and Version

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