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    gon-4 GON-4-like protein [ Caenorhabditis elegans ]

    Gene ID: 177899, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gon-4
    Official Full Name
    GON-4-like protein
    Primary source
    WormBase:WBGene00001653
    Locus tag
    CELE_K04D7.5
    See related
    AllianceGenome:WB:WBGene00001653
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable transcription coregulator activity. Involved in gonad development and positive regulation of cell division. Located in germ cell nucleus. Is expressed in germ line and gonad. Orthologous to human YY1AP1 (YY1 associated protein 1) and GON4L (gon-4 like). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See gon-4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    14
    Sequence:
    Chromosome: IV; NC_003282.8 (10197817..10202993)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Tyrosine-protein phosphatase 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Serpentine receptor class gamma Neighboring gene ABC transporter domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The promotion of gonadal cell divisions by the Caenorhabditis elegans TRPM cation channel GON-2 is antagonized by GEM-4 copine. Church DL, et al. Genetics, 2003 Oct. PMID 14573470, Free PMC Article
    2. gon-4, a cell lineage regulator required for gonadogenesis in Caenorhabditis elegans. Friedman L, et al. Dev Biol, 2000 Dec 15. PMID 11112335
    3. The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad. Siegfried KR, et al. Genetics, 2004 Jan. PMID 15020416, Free PMC Article
    4. Cyclin D regulation of a sexually dimorphic asymmetric cell division. Tilmann C, et al. Dev Cell, 2005 Oct. PMID 16198291, Free PMC Article
    5. Cell-Specific mRNA Profiling of the Caenorhabditis elegans Somatic Gonadal Precursor Cells Identifies Suites of Sex-Biased and Gonad-Enriched Transcripts. Kroetz MB, et al. G3 (Bethesda), 2015 Oct 23. PMID 26497144, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GON-4-like protein
    NP_001122786.1
    • Confirmed by transcript evidence
    NP_501864.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      10197817..10202993
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_069463.7 → NP_501864.2  GON-4-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501864.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21216

    2. NM_001129314.4 → NP_001122786.1  GON-4-like protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122786.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5JYS9
    Nucleotide Protein
    Heading Accession and Version

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