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    mdf-2 HORMA domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177046, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mdf-2
    Official Full Name
    HORMA domain-containing protein
    Primary source
    WormBase:WBGene00003161
    Locus tag
    CELE_Y69A2AR.30
    See related
    AllianceGenome:WB:WBGene00003161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in embryo development; mitotic spindle assembly checkpoint signaling; and response to anoxia. Located in kinetochore; microtubule cytoskeleton; and nucleus. Is expressed in germ line. Orthologous to human MAD2L1 (mitotic arrest deficient 2 like 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mdf-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    5
    Sequence:
    Chromosome: IV; NC_003282.8 (2636229..2641025, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene NRAMP-like transporter smf-3 Neighboring gene Helix-loop-helix protein ngn-1 Neighboring gene ncRNA Neighboring gene tRNA-Glu Neighboring gene NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial Neighboring gene Chaperone ric-8;Synembryn;Synembryn-A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans. Devigne A, et al. PLoS Genet, 2021 Nov. PMID 34762652, Free PMC Article
    2. Loss of the puromycin-sensitive aminopeptidase, PAM-1, triggers the spindle assembly checkpoint during the first mitotic division in Caenorhabditis elegans. Durkan A, et al. MicroPubl Biol, 2024. PMID 38633870, Free PMC Article
    3. Suspended animation in C. elegans requires the spindle checkpoint. Nystul TG, et al. Science, 2003 Nov 7. PMID 14605367
    4. TRIP13PCH-2 promotes Mad2 localization to unattached kinetochores in the spindle checkpoint response. Nelson CR, et al. J Cell Biol, 2015 Nov 9. PMID 26527744, Free PMC Article
    5. Spindle assembly checkpoint genes reveal distinct as well as overlapping expression that implicates MDF-2/Mad2 in postembryonic seam cell proliferation in Caenorhabditis elegans. Tarailo-Graovac M, et al. BMC Cell Biol, 2010 Sep 21. PMID 20858267, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans.
      Title: Mad1's ability to interact with Mad2 is essential to regulate and monitor meiotic synapsis in C. elegans.
    2. A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores.
      Title: A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores.
    3. spindle assembly checkpoint components MAD-1, MAD-2, and BUB-3 are required to negatively regulate synapsis and promote the synapsis checkpoint response.
      Title: Spindle assembly checkpoint proteins regulate and monitor meiotic synapsis in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in embryo development ending in birth or egg hatching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to anoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HORMA domain-containing protein
    NP_001023563.1
    • Confirmed by transcript evidence
    NP_001294613.1
    • Confirmed by transcript evidence
    NP_001370850.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2636229..2641025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383055.1 → NP_001370850.1  HORMA domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T870
      Conserved Domains (1) summary
      pfam02301
      Location:15 → 104
      HORMA; HORMA domain

    2. NM_001028392.8 → NP_001023563.1  HORMA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023563.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NGT3
      Conserved Domains (1) summary
      pfam02301
      Location:15 → 191
      HORMA; HORMA domain

    3. NM_001307684.3 → NP_001294613.1  HORMA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294613.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PC21
      Conserved Domains (1) summary
      pfam02301
      Location:11 → 128
      HORMA; HORMA domain
    Nucleotide Protein
    Heading Accession and Version

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