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    pes-4 K Homology domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 175288, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pes-4
    Official Full Name
    K Homology domain-containing protein
    Primary source
    WormBase:WBGene00003978
    Locus tag
    CELE_Y119D3B.17
    See related
    AllianceGenome:WB:WBGene00003978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in regulation of RNA metabolic process and regulation of gene expression. Predicted to be active in cytoplasm and nucleus. Is expressed in pharynx and rectal epithelium. Orthologous to several human genes including PCBP1 (poly(rC) binding protein 1); PCBP2 (poly(rC) binding protein 2); and PCBP3 (poly(rC) binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pes-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (1216488..1222072, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ORC_WH_C domain-containing protein Neighboring gene Protein KRI1 homolog Neighboring gene ncRNA Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular markers of differentiation in Caenorhabditis elegans obtained by promoter trapping. Young JM, et al. Dev Dyn, 1993 Feb. PMID 8364222
    2. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of RNA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    K Homology domain-containing protein
    NP_497351.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1216488..1222072 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064950.7 → NP_497351.3  K Homology domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497351.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Y67
      Conserved Domains (1) summary
      cd02396
      Location:154 → 218
      PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
    Nucleotide Protein
    Heading Accession and Version

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