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    F54A3.2 TOG domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186196, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F54A3.2
    Official Full Name
    TOG domain-containing protein
    Primary source
    WormBase:WBGene00018781
    Locus tag
    CELE_F54A3.2
    See related
    AllianceGenome:WB:WBGene00018781
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable microtubule binding activity and microtubule plus end polymerase. Predicted to be involved in microtubule cytoskeleton organization. Predicted to be located in intracellular non-membrane-bounded organelle and supramolecular complex. Predicted to be active in centrosome; kinetochore; and spindle pole. Predicted to colocalize with microtubule plus-end. Orthologous to human CKAP5 (cytoskeleton associated protein 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F54A3.2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    10
    Sequence:
    Chromosome: II; NC_003280.10 (2243642..2254368)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Periphilin-1-like;Trithorax group protein osa Neighboring gene ncRNA Neighboring gene T-complex protein 1 subunit gamma Neighboring gene ncRNA Neighboring gene WSN domain-containing protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus end polymerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule plus end polymerase IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule plus-end binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome duplication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of microtubule cytoskeleton polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment or maintenance of microtubule cytoskeleton polarity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in microtubule polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membraneless organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in supramolecular complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TOG domain-containing protein
    NP_494219.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      2243642..2254368
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061818.6 → NP_494219.4  TOG domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_494219.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9N4J7
      Conserved Domains (2) summary
      pfam15292
      Location:387 → 489
      Treslin_N; Treslin N-terminus
      sd00044
      Location:103 → 132
      HEAT; HEAT repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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