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    Y18H1A.11 choline-phosphate cytidylyltransferase [ Caenorhabditis elegans ]

    Gene ID: 353380, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y18H1A.11
    Official Full Name
    choline-phosphate cytidylyltransferase
    Primary source
    WormBase:WBGene00021215
    Locus tag
    CELE_Y18H1A.11
    See related
    AllianceGenome:WB:WBGene00021215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable choline-phosphate cytidylyltransferase activity and phosphatidylcholine binding activity. Predicted to be involved in CDP-choline pathway. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy and spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to human PCYT1A (phosphate cytidylyltransferase 1A, choline) and PCYT1B (phosphate cytidylyltransferase 1B, choline). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y18H1A.11 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (673165..683472)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene Cytidyltransferase-like domain-containing protein Neighboring gene Protein kinase domain-containing protein Neighboring gene Glycosyltransferase family 92 protein Neighboring gene non-specific serine/threonine protein kinase Neighboring gene Tyrosine-protein phosphatase domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables choline-phosphate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    choline-phosphate cytidylyltransferase
    NP_001293179.1
    • Confirmed by transcript evidence
    NP_001293180.1
    • Confirmed by transcript evidence
    NP_001370918.1
    • Confirmed by transcript evidence
    NP_871893.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      673165..683472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383163.1 → NP_001370918.1  choline-phosphate cytidylyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CL91
      Conserved Domains (1) summary
      cd02174
      Location:45 → 184
      CCT; CTP:phosphocholine cytidylyltransferase

    2. NM_182093.5 → NP_871893.1  choline-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_871893.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IU09
      Conserved Domains (1) summary
      cd02174
      Location:45 → 194
      CCT; CTP:phosphocholine cytidylyltransferase

    3. NM_001306250.3 → NP_001293179.1  choline-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293179.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CIU7
      Conserved Domains (1) summary
      cd02174
      Location:1 → 138
      CCT; CTP:phosphocholine cytidylyltransferase

    4. NM_001306251.3 → NP_001293180.1  choline-phosphate cytidylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293180.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJZ8
      Conserved Domains (1) summary
      cl00015
      Location:1 → 128
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein
    Heading Accession and Version

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