let-363 Target of rapamycin homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: let-363
Official Full Name: Target of rapamycin homolog
Primary source: WormBase:WBGene00002583
Locus tag: CELE_B0261.2
See related: AllianceGenome:WB:WBGene00002583
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including box C/D snoRNP assembly; determination of adult lifespan; and regulation of gene expression. Located in cytoplasm. Part of TORC1 complex and TORC2 complex. Is expressed in several structures, including intestine; muscle cell; neurons; pharynx; and vulva. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; kidney angiomyolipoma; lung disease (multiple); prostate cancer; and type 2 diabetes mellitus. Orthologous to human MTOR (mechanistic target of rapamycin kinase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See let-363 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 32

Sequence:: Chromosome: I; NC_003279.8 (5245743..5263424)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Rheb-TORC1 signaling axis functions as a developmental checkpoint.
Title: The Rheb-TORC1 signaling axis functions as a developmental checkpoint.
Dafachronic acid signaling through let-363 is essential for diet restriction-mediated longevity.
Title: Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans.
influence on lifespan
Title: Genetics: influence of TOR kinase on lifespan in C. elegans.
Mutations result in dauer-like larval arrest, implying that CeTOR (let-363)regulates dauer diapause.
Title: The TOR pathway interacts with the insulin signaling pathway to regulate C. elegans larval development, metabolism and life span.
C. elegans target of rapamycin (TOR) and the DAF-2/insulin-signaling pathways cross-talk with pep-2
Title: Deletion of the intestinal peptide transporter affects insulin and TOR signaling in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0261.6 (e-PCR)
- UniSTS:317808

B0261.2 (e-PCR)
- UniSTS:308361

B0261.5 (e-PCR)
- UniSTS:315301

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in box C/D snoRNP assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesendoderm development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to sodium arsenite	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC1 complex	IEA Inferred from Electronic Annotation more info
part_of TORC1 complex	ISS Inferred from Sequence or Structural Similarity more info
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of TORC2 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Target of rapamycin homolog

NP_491549.2

Confirmed by transcript evidence

NP_491552.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5245743..5263424

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059148.6 → NP_491549.2 Target of rapamycin homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491549.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O01438, Q95Q95

Conserved Domains (7) summary

COG5032
Location:683 → 2695

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

pfam04554
Location:1970 → 2032

Extensin_2; Extensin-like region

cd05169
Location:2327 → 2606

PIKKc_TOR; Catalytic domain of Target of Rapamycin

pfam02260
Location:2664 → 2695

FATC; FATC domain

pfam08771
Location:2188 → 2286

Rapamycin_bind; Rapamycin binding domain

pfam11865
Location:854 → 1028

DUF3385; Domain of unknown function (DUF3385)

sd00044
Location:654 → 683

HEAT; HEAT repeat [structural motif]
NM_059151.7 → NP_491552.2 Target of rapamycin homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491552.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O01438, Q95Q95

Conserved Domains (7) summary

COG5032
Location:683 → 2692

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]

pfam04554
Location:1970 → 2029

Extensin_2; Extensin-like region

cd05169
Location:2324 → 2603

PIKKc_TOR; Catalytic domain of Target of Rapamycin

pfam02260
Location:2661 → 2692

FATC; FATC domain

pfam08771
Location:2185 → 2283

Rapamycin_bind; Rapamycin binding domain

pfam11865
Location:854 → 1028

DUF3385; Domain of unknown function (DUF3385)

sd00044
Location:654 → 683

HEAT; HEAT repeat [structural motif]