U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    pac-1 GTPase-activating protein pac-1;PH domain-containing protein;Rho-GAP domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 176201, updated on 9-Dec-2024

    Summary

    Official Symbol
    pac-1
    Official Full Name
    GTPase-activating protein pac-1;PH domain-containing protein;Rho-GAP domain-containing protein
    Primary source
    WormBase:WBGene00015418
    Locus tag
    CELE_C04D8.1
    See related
    AllianceGenome:WB:WBGene00015418
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase activator activity. Involved in protein localization; regulation of gastrulation; and small GTPase-mediated signal transduction. Located in cell junction. Is expressed in anus; epithelial cell; hypodermis; muscle cell; and pharynx. Orthologous to human ARHGAP23 (Rho GTPase activating protein 23). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See pac-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    20
    Sequence:
    Chromosome: III; NC_003281.10 (8495008..8518916)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Interactions

    General gene information

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables GTPase activator activity PubMed 
    enables GTPase activator activity  
    enables protein binding PubMed 
    Component Evidence Code Pubs
    located_in adherens junction  
    located_in anchoring junction  
    located_in cell junction PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    is_active_in plasma membrane  

    General protein information

    Preferred Names
    GTPase-activating protein pac-1;PH domain-containing protein;Rho-GAP domain-containing protein
    NP_001129833.1
    • Confirmed by transcript evidence
    NP_001293654.1
    • Confirmed by transcript evidence
    NP_001293655.1
    • Confirmed by transcript evidence
    NP_001293656.1
    • Partially confirmed by transcript evidence
    NP_001293657.1
    • Confirmed by transcript evidence
    NP_498877.4
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8495008..8518916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306728.4 → NP_001293657.1  GTPase-activating protein pac-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293657.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PRC7
      Conserved Domains (3) summary
      cd04395
      Location:944 → 1145
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:612 → 727
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:616 → 725
      PH; PH domain
    2. NM_001136361.5 → NP_001129833.1  GTPase-activating protein pac-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129833.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34288
      Conserved Domains (3) summary
      cd04395
      Location:944 → 1145
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:612 → 727
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:616 → 725
      PH; PH domain
    3. NM_066476.7 → NP_498877.4  GTPase-activating protein pac-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498877.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3VIA5, B5MBW1, P34288, P34414, P34588, P34589, Q8ST20, Q9TY64
      Conserved Domains (2) summary
      cd04395
      Location:945 → 1146
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
      cd01253
      Location:613 → 728
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
    4. NM_001306727.4 → NP_001293656.1  PH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293656.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PM34
      Conserved Domains (3) summary
      cd04395
      Location:583 → 784
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:251 → 366
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:255 → 364
      PH; PH domain
    5. NM_001306725.3 → NP_001293654.1  PH domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293654.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBA1
      Conserved Domains (3) summary
      cd04395
      Location:478 → 679
      RhoGAP_ARHGAP21; RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the ...
      cd01253
      Location:146 → 261
      PH_ARHGAP21-like; ARHGAP21 and related proteins pleckstrin homology (PH) domain
      pfam00169
      Location:150 → 259
      PH; PH domain
    6. NM_001306726.3 → NP_001293655.1  Rho-GAP domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293655.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PBN0
      Conserved Domains (1) summary
      cd04395
      Location:106 → 307
      RhoGAP_ARHGAP21; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction ...
    External link. Please review our privacy policy.