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    dig-1 Mesocentin [ Caenorhabditis elegans ]

    Gene ID: 175951, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dig-1
    Official Full Name
    Mesocentin
    Primary source
    WormBase:WBGene00000998
    Locus tag
    CELE_K07E12.1
    See related
    AllianceGenome:WB:WBGene00000998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Is expressed in several structures, including GLR; body wall musculature; head mesodermal cell; male sex myoblast; and non-striated muscle. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dig-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    48
    Sequence:
    Chromosome: III; NC_003281.10 (6746308..6794764)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DIG-1, a novel giant protein, non-autonomously mediates maintenance of nervous system architecture. Bénard CY, et al. Development, 2006 Sep. PMID 16887823
    2. The C. elegans gene dig-1 encodes a giant member of the immunoglobulin superfamily that promotes fasciculation of neuronal processes. Burket CT, et al. Dev Biol, 2006 Nov 1. PMID 16928366
    3. Loss of the Extracellular Matrix Protein DIG-1 Causes Glial Fragmentation, Dendrite Breakage, and Dendrite Extension Defects. Chong MK, et al. J Dev Biol, 2021 Oct 7. PMID 34698211, Free PMC Article
    4. Logic programming to predict cell fate patterns and retrodict genotypes in organogenesis. Hall BA, et al. J R Soc Interface, 2014 Sep 6. PMID 24966232, Free PMC Article
    5. Cell interactions coordinate the development of the C. elegans egg-laying system. Thomas JH, et al. Cell, 1990 Sep 21. PMID 2401010

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DIG-1 functions post-developmentally to maintain axons and cell bodies in place within axonal fascicles and ganglia.
      Title: DIG-1, a novel giant protein, non-autonomously mediates maintenance of nervous system architecture.
    2. Mutant phenotypes suggest that DIG-1 may mediate cell movement as well as process fasciculation and that different regions of the protein may mediate these functions.
      Title: The C. elegans gene dig-1 encodes a giant member of the immunoglobulin superfamily that promotes fasciculation of neuronal processes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mesocentin
    NP_001366805.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      6746308..6794764
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379776.1 → NP_001366805.1  Mesocentin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09165, Q8MTB9
      UniProtKB/TrEMBL
      A0A679L8M9
      Conserved Domains (12) summary
      smart00060
      Location:394 → 478
      FN3; Fibronectin type 3 domain
      smart00179
      Location:12972 → 13013
      EGF_CA; Calcium-binding EGF-like domain
      smart00327
      Location:12151 → 12302
      VWA; von Willebrand factor (vWF) type A domain
      COG1520
      Location:11141 → 11487
      PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
      cd00063
      Location:993 → 1089
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd01450
      Location:12363 → 12522
      vWFA_subfamily_ECM; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      pfam00047
      Location:1824 → 1903
      ig; Immunoglobulin domain
      pfam13927
      Location:1202 → 1268
      Ig_3; Immunoglobulin domain
      pfam14670
      Location:226 → 262
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cd00096
      Location:1828 → 1831
      Ig; Ig strand A' [structural motif]
      cl00057
      Location:6583 → 6690
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
      cl11960
      Location:497 → 578
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version

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