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    mca-2 Calcium-transporting ATPase [ Caenorhabditis elegans ]

    Gene ID: 177004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mca-2
    Official Full Name
    Calcium-transporting ATPase
    Primary source
    WormBase:WBGene00019875
    Locus tag
    CELE_R05C11.3
    See related
    AllianceGenome:WB:WBGene00019875
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable P-type calcium transporter activity. Predicted to be involved in regulation of cytosolic calcium ion concentration. Predicted to be located in membrane. Predicted to be active in intracellular membrane-bounded organelle and plasma membrane. Is expressed in hypodermis. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; autosomal dominant nonsyndromic deafness; and autosomal recessive nonsyndromic deafness 12. Orthologous to several human genes including ATP2B1 (ATPase plasma membrane Ca2+ transporting 1); ATP2B2 (ATPase plasma membrane Ca2+ transporting 2); and ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mca-2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    11
    Sequence:
    Chromosome: IV; NC_003282.8 (2084034..2091919)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Carbon storage regulator;G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and functional expression of the plasma membrane calcium ATPase gene family from Caenorhabditis elegans. Kraev A, et al. J Biol Chem, 1999 Feb 12. PMID 9933625
    2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    3. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article
    4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type calcium transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables P-type calcium transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Calcium-transporting ATPase
    NP_500161.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      2084034..2091919
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067760.6 → NP_500161.1  Calcium-transporting ATPase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500161.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O76833, Q9TYP9
      Conserved Domains (7) summary
      TIGR01517
      Location:5 → 1026
      ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
      pfam00122
      Location:168 → 413
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:841 → 1020
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:35 → 101
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12424
      Location:1073 → 1096
      ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
      pfam12710
      Location:648 → 767
      HAD; haloacid dehalogenase-like hydrolase
      pfam13246
      Location:475 → 564
      Cation_ATPase; Cation transport ATPase (P-type)
    Nucleotide Protein
    Heading Accession and Version

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