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    Mvb12 Multivesicular body subunit 12 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32791, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mvb12provided by FlyBase
    Official Full Name
    Multivesicular body subunit 12provided by FlyBase
    Primary source
    FLYBASE:FBgn0030894
    Locus tag
    Dmel_CG7192
    See related
    AllianceGenome:FB:FBgn0030894
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7192; Dmel\CG7192
    Summary
    Predicted to enable ubiquitin binding activity. Predicted to be involved in several processes, including endosome to lysosome transport via multivesicular body sorting pathway; receptor catabolic process; and regulation of epidermal growth factor receptor signaling pathway. Predicted to be part of ESCRT I complex. Predicted to be active in cytosol. Orthologous to several human genes including MVB12A (multivesicular body subunit 12A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mvb12 in Genome Data Viewer
    Location:
    16F6-16F6; 1-59 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18097558..18101314, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (17991591..17995347, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene scully Neighboring gene Rho GTPase activating protein at 16F Neighboring gene TBP-associated factor 8 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Neuronal activity induces glucosylceramide that is secreted via exosomes for lysosomal degradation in glia. Wang L, et al. Sci Adv, 2022 Jul 15. PMID 35857503, Free PMC Article
    2. Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles. Thomas RE, et al. PLoS Genet, 2018 Sep. PMID 30256786, Free PMC Article
    3. Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. Vaccari T, et al. J Cell Sci, 2009 Jul 15. PMID 19571114, Free PMC Article
    4. Developmental and cellular functions of the ESCRT machinery in pluricellular organisms. Michelet X, et al. Biol Cell, 2010 Jan 13. PMID 20059450
    5. The vacuolar protein sorting genes in insects: A comparative genome view. Li Z, et al. Insect Biochem Mol Biol, 2015 Jul. PMID 25486452

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in endosome to lysosome transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in viral budding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in virus maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT I complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ESCRT I complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    multivesicular body subunit 12
    Names
    CG7192-PA
    CG7192-PB
    CG7192-PD
    Mvb12-PA
    Mvb12-PB
    Mvb12-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18097558..18101314 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133040.3 → NP_573268.1  multivesicular body subunit 12, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573268.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWY7
      Related
      FBpp0074301
      Conserved Domains (1) summary
      pfam10240
      Location:56 → 334
      DUF2464; Protein of unknown function (DUF2464)

    2. NM_001258802.1 → NP_001245731.1  multivesicular body subunit 12, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245731.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWY7
      Conserved Domains (1) summary
      pfam10240
      Location:56 → 334
      DUF2464; Protein of unknown function (DUF2464)

    3. NM_167602.2 → NP_728135.1  multivesicular body subunit 12, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728135.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWY7
      Related
      FBpp0074302
      Conserved Domains (1) summary
      pfam10240
      Location:56 → 334
      DUF2464; Protein of unknown function (DUF2464)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VWY7 Q9VWY7

    Gene LinkOut

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