CG43980 uncharacterized protein [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CG43980provided by FlyBase
Official Full Name: uncharacterized proteinprovided by FlyBase
Primary source: FLYBASE:FBgn0264711
Locus tag: Dmel_CG43980
See related: AllianceGenome:FB:FBgn0264711
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG11250; CG33291; CG33292; Dmel\CG43980
Old locus tag: Dmel_CG33291; Dmel_CG33292
Summary: Predicted to enable protein heterodimerization activity. Is expressed in several structures, including antennal primordium; central brain primordium; dorsal ectoderm; dorsal epidermis primordium; and head epidermis primordium. Orthologous to human ABTB2 (ankyrin repeat and BTB domain containing 2) and ABTB3 (ankyrin repeat and BTB domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 78E2-78E2; 3-47 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (21644958..21666306)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (21638058..21659406)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: 21646923-21646959 mobile_element_type = transposon:INE-1{}2063

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: uncharacterized protein

Names: CG43980-PB; CG43980-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

21644958..21666306

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206420.2 → NP_996142.1 uncharacterized protein Dmel_CG43980, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996142.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7KTV4

Conserved Domains (8) summary

smart00225
Location:1133 → 1226

BTB; Broad-Complex, Tramtrack and Bric a brac

cd00204
Location:783 → 940

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14821
Location:1233 → 1269

SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

pfam00651
Location:1127 → 1223

BTB; BTB/POZ domain

pfam11235
Location:42 → 201

Med25_SD1; Mediator complex subunit 25 synapsin 1

pfam12796
Location:793 → 899

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:789 → 833

ANK; ANK repeat [structural motif]

cl23907
Location:452 → 500

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...
NM_001275256.1 → NP_001262185.1 uncharacterized protein Dmel_CG43980, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262185.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PFY3

Conserved Domains (8) summary

smart00225
Location:1356 → 1449

BTB; Broad-Complex, Tramtrack and Bric a brac

cd00204
Location:1006 → 1163

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd14821
Location:1456 → 1492

SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

pfam00651
Location:1350 → 1446

BTB; BTB/POZ domain

pfam11235
Location:265 → 424

Med25_SD1; Mediator complex subunit 25 synapsin 1

pfam12796
Location:1016 → 1122

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:1012 → 1056

ANK; ANK repeat [structural motif]

cl23907
Location:675 → 728

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...