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    eRF1 eukaryotic translation release factor 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40240, updated on 9-Dec-2024

    Summary

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    Official Symbol
    eRF1provided by FlyBase
    Official Full Name
    eukaryotic translation release factor 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036974
    Locus tag
    Dmel_CG5605
    See related
    AllianceGenome:FB:FBgn0036974
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5605; deRF1; Dm0184; Dmel\CG5605; group J; Group J; l(3)00103; l(3)05637; l(3)77ABb; l(3)neo28
    Summary
    Predicted to enable sequence-specific mRNA binding activity and translation release factor activity, codon specific. Involved in translational termination. Predicted to be part of translation release factor complex. Predicted to be active in cytosol. Is expressed in adult head; adult heart; and organism. Orthologous to human ETF1 (eukaryotic translation termination factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See eRF1 in Genome Data Viewer
    Location:
    77B4-77B5; 3-47 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20348355..20353873)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20341455..20346973)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Serpin 77Bc Neighboring gene pseudo Neighboring gene Retinoblastoma binding protein 5 Neighboring gene uncharacterized protein Neighboring gene kin17 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons. Yang Q, et al. Nucleic Acids Res, 2019 Sep 26. PMID 31410471, Free PMC Article
    2. Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity. Ortega JA, et al. Neuron, 2020 Apr 8. PMID 32059759, Free PMC Article
    3. HemK2 functions for sufficient protein synthesis and RNA stability through eRF1 methylation during Drosophila oogenesis. Xu F, et al. Development, 2024 Jul 15. PMID 38881530
    4. Drosophila Caliban preserves intestinal homeostasis and lifespan through regulating mitochondrial dynamics and redox state in enterocytes. Dai Z, et al. PLoS Genet, 2020 Oct. PMID 33057338, Free PMC Article
    5. Mutations in eukaryotic release factors 1 and 3 act as general nonsense suppressors in Drosophila. Chao AT, et al. Genetics, 2003 Oct. PMID 14573473, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sequence-specific mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation release factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation release factor activity, codon specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational termination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of translation release factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation release factor 1
    Names
    CG5605-PA
    CG5605-PB
    CG5605-PC
    CG5605-PE
    CG5605-PF
    CG5605-PG
    CG5605-PH
    CG5605-PI
    eRF1-PA
    eRF1-PB
    eRF1-PC
    eRF1-PE
    eRF1-PF
    eRF1-PG
    eRF1-PH
    eRF1-PI
    eukaryotic release factor 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20348355..20353873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275176.1 → NP_001262105.1  eukaryotic translation release factor 1, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262105.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PFR9
      Conserved Domains (4) summary
      COG1503
      Location:11 → 414
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
      pfam03463
      Location:18 → 136
      eRF1_1; eRF1 domain 1
      pfam03464
      Location:145 → 277
      eRF1_2; eRF1 domain 2
      pfam03465
      Location:280 → 414
      eRF1_3; eRF1 domain 3

    2. NM_140953.3 → NP_649210.1  eukaryotic translation release factor 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649210.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V259, Q0E8C7, Q8T071, Q9VPH7
      UniProtKB/TrEMBL
      D1Z373
      Related
      FBpp0077835
      Conserved Domains (1) summary
      COG1503
      Location:11 → 420
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

    3. NM_168847.2 → NP_730519.1  eukaryotic translation release factor 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730519.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V259, Q0E8C7, Q8T071, Q9VPH7
      UniProtKB/TrEMBL
      D1Z373
      Related
      FBpp0077833
      Conserved Domains (1) summary
      COG1503
      Location:11 → 420
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

    4. NM_168845.2 → NP_730517.1  eukaryotic translation release factor 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730517.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V259, Q0E8C7, Q8T071, Q9VPH7
      UniProtKB/TrEMBL
      D1Z373
      Related
      FBpp0077832
      Conserved Domains (1) summary
      COG1503
      Location:11 → 420
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

    5. NM_168848.2 → NP_730520.1  eukaryotic translation release factor 1, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730520.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V259, Q0E8C7, Q8T071, Q9VPH7
      UniProtKB/TrEMBL
      D1Z373
      Related
      FBpp0077834
      Conserved Domains (1) summary
      COG1503
      Location:11 → 420
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

    6. NM_168846.2 → NP_730518.1  eukaryotic translation release factor 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730518.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V259, Q0E8C7, Q8T071, Q9VPH7
      UniProtKB/TrEMBL
      D1Z373
      Related
      FBpp0077831
      Conserved Domains (1) summary
      COG1503
      Location:11 → 420
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

    7. NM_001275175.1 → NP_001262104.1  eukaryotic translation release factor 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262104.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PD27
      Conserved Domains (1) summary
      COG1503
      Location:11 → 420
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

    8. NM_176369.3 → NP_788547.1  eukaryotic translation release factor 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V259, Q0E8C7, Q8T071, Q9VPH7
      UniProtKB/TrEMBL
      D1Z373
      Related
      FBpp0077836
      Conserved Domains (1) summary
      COG1503
      Location:11 → 420
      eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PD27 M9PD27
    M9PFR9 M9PFR9
    Q9VPH7.2 Q9VPH7

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