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    Axud1 AXIN1 up-regulated 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33419, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Axud1provided by FlyBase
    Official Full Name
    AXIN1 up-regulated 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0261647
    Locus tag
    Dmel_CG4272
    See related
    AllianceGenome:FB:FBgn0261647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH09817; C676; CG4272; DAxud1; Dmel\CG4272
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in negative regulation of cell population proliferation. Located in nucleus. Is expressed in several structures, including cephalic furrow; eye disc anterior to the morphogenetic furrow; germ band; imaginal disc; and presumptive embryonic/larval system. Orthologous to several human genes including CSRNP1 (cysteine and serine rich nuclear protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Axud1 in Genome Data Viewer
    Location:
    22E1-22E1; 2-6 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2365345..2370137)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2365345..2370137)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene eyes shut Neighboring gene Rab5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila DAxud1 Has a Repressive Transcription Activity on Hsp70 and Other Heat Shock Genes. Zuñiga-Hernandez J, et al. Int J Mol Sci, 2023 Apr 19. PMID 37108646, Free PMC Article
    2. Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release. Wucherpfennig T, et al. J Cell Biol, 2003 May 12. PMID 12743108, Free PMC Article
    3. Characterization of a family of novel cysteine- serine-rich nuclear proteins (CSRNP). Gingras S, et al. PLoS One, 2007 Aug 29. PMID 17726538, Free PMC Article
    4. CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution. Wang Q, et al. Nat Commun, 2021 May 26. PMID 34039988, Free PMC Article
    5. The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain. Mahr A, et al. Gene Expr Patterns, 2006 Mar. PMID 16378756

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila DAxud1 Has a Repressive Transcription Activity on Hsp70 and Other Heat Shock Genes.
      Title: Drosophila DAxud1 Has a Repressive Transcription Activity on Hsp70 and Other Heat Shock Genes.
    2. Drosophila Axud1 behaves as a tumor suppressor that regulates the proliferation rhythm of imaginal cells.
      Title: Drosophila Axud1 is involved in the control of proliferation and displays pro-apoptotic activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    AXIN1 up-regulated 1
    Names
    Axud1-PA
    Axud1-PB
    Axud1-PC
    Axud1-PD
    CG4272-PA
    CG4272-PB
    CG4272-PC
    CG4272-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2365345..2370137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272999.1 → NP_001259928.1  AXIN1 up-regulated 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259928.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U4G5, Q9VQB2
      Conserved Domains (2) summary
      PHA03255
      Location:643 → 786
      PHA03255; BDLF3; Provisional
      pfam16019
      Location:301 → 500
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    2. NM_134829.3 → NP_608673.1  AXIN1 up-regulated 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608673.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U4G5, Q9VQB2
      Related
      FBpp0077442
      Conserved Domains (2) summary
      PHA03255
      Location:643 → 786
      PHA03255; BDLF3; Provisional
      pfam16019
      Location:301 → 500
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    3. NM_164480.2 → NP_722800.1  AXIN1 up-regulated 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_722800.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U4G5, Q9VQB2
      Related
      FBpp0077443
      Conserved Domains (2) summary
      PHA03255
      Location:643 → 786
      PHA03255; BDLF3; Provisional
      pfam16019
      Location:301 → 500
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus

    4. NM_001273000.1 → NP_001259929.1  AXIN1 up-regulated 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259929.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U4G5, Q9VQB2
      Conserved Domains (2) summary
      PHA03255
      Location:643 → 786
      PHA03255; BDLF3; Provisional
      pfam16019
      Location:301 → 500
      CSRNP_N; Cysteine/serine-rich nuclear protein N-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U4G5 Q9U4G5

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