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    RtGEF Rho-type guanine nucleotide exchange factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35306, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RtGEFprovided by FlyBase
    Official Full Name
    Rho-type guanine nucleotide exchange factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015803
    Locus tag
    Dmel_CG10043
    See related
    AllianceGenome:FB:FBgn0015803
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    38C.40; ARHGEF7; beta-PIX; betaPIX; CG10043; Dmel\CG10043; dpix; dPix; dPIX; DrhoGEF; DrtGEF; pix; Pix; Rho/RacGEF; rhoGEF; RhoGEF; rtGEF
    Summary
    Enables molecular adaptor activity. Involved in negative regulation of organ growth; positive regulation of hippo signaling; and regulation of synapse organization. Located in muscle cell postsynaptic specialization. Is expressed in several structures, including amnioproctodeal invagination; embryonic/larval midgut primordium; epithelial furrow; female germline cell; and organism subdivision. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to several human genes including ARHGEF6 (Rac/Cdc42 guanine nucleotide exchange factor 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RtGEF in Genome Data Viewer
    Location:
    38C5-38C5; 2-54 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20350434..20365254)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20350434..20365254)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43606 Neighboring gene spire Neighboring gene La autoantigen-like Neighboring gene UDP-glycosyltransferase family 37 member A1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Drosophila gene with predicted rhoGEF, pleckstrin homology and SH3 domains is highly expressed in morphogenic tissues. Werner LA, et al. Gene, 1997 Mar 10. PMID 9073073
    2. DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern. Hicks MS, et al. Dev Genes Evol, 2001 May. PMID 11455443
    3. Genetic analysis of a La homolog in Drosophila melanogaster. Bai C, et al. Nucleic Acids Res, 2000 Mar 1. PMID 10666446, Free PMC Article
    4. Neto-mediated intracellular interactions shape postsynaptic composition at the Drosophila neuromuscular junction. Ramos CI, et al. PLoS Genet, 2015 Apr. PMID 25905467, Free PMC Article
    5. The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development. Dent LG, et al. PLoS Genet, 2019 May. PMID 31116733, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pix and Git regulate Hippo-pathway-dependent tissue growth.
      Title: The GTPase regulatory proteins Pix and Git control tissue growth via the Hippo pathway.
    2. A novel RhoGEF(Pbl)-dependent input promotes the simultaneous association of anillin with the plasma membrane, septins, and microtubules, independently of F-actin.
      Title: Rho-dependent control of anillin behavior during cytokinesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of organ growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in muscle cell postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rho-type guanine nucleotide exchange factor
    Names
    CG10043-PA
    CG10043-PB
    CG10043-PD
    CG10043-PE
    CG10043-PF
    CG10043-PG
    CG10043-PH
    CG10043-PI
    PAK-interacting exchange factor
    RtGEF-PA
    RtGEF-PB
    RtGEF-PD
    RtGEF-PE
    RtGEF-PF
    RtGEF-PG
    RtGEF-PH
    RtGEF-PI
    drosophila rho-type guanine exchange factor
    rho-type guanine exchange factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20350434..20365254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103715.4 → NP_001097185.2  Rho-type guanine nucleotide exchange factor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097185.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ20
      Conserved Domains (5) summary
      cd11877
      Location:6 → 58
      SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
      cd00160
      Location:79 → 249
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:281 → 376
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:294 → 372
      PH; PH domain
      pfam16614
      Location:543 → 610
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    2. NM_057826.5 → NP_477174.1  Rho-type guanine nucleotide exchange factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477174.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62527, Q9VIN1
      Related
      FBpp0080888
      Conserved Domains (5) summary
      cd11877
      Location:6 → 58
      SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
      cd00160
      Location:79 → 249
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:281 → 376
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:294 → 372
      PH; PH domain
      pfam16614
      Location:543 → 610
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    3. NM_001169550.2 → NP_001163021.1  Rho-type guanine nucleotide exchange factor, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163021.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C3KGL5, O62527
      Conserved Domains (5) summary
      cd11877
      Location:6 → 58
      SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
      cd00160
      Location:79 → 249
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:281 → 376
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:294 → 372
      PH; PH domain
      pfam16614
      Location:543 → 610
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    4. NM_001273694.1 → NP_001260623.1  Rho-type guanine nucleotide exchange factor, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260623.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PBE8
      Conserved Domains (4) summary
      cd11877
      Location:6 → 58
      SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
      cd00160
      Location:79 → 249
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:281 → 376
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:294 → 372
      PH; PH domain

    5. NM_001103714.3 → NP_001097184.2  Rho-type guanine nucleotide exchange factor, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097184.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ19
      Conserved Domains (3) summary
      cd11877
      Location:6 → 58
      SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
      cd00160
      Location:79 → 249
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:281 → 376
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain

    6. NM_165327.3 → NP_724258.1  Rho-type guanine nucleotide exchange factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724258.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O62527, Q9VIN1
      Related
      FBpp0080889
      Conserved Domains (5) summary
      cd11877
      Location:6 → 58
      SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
      cd00160
      Location:79 → 249
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:281 → 376
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:294 → 372
      PH; PH domain
      pfam16614
      Location:543 → 610
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    7. NM_001273693.1 → NP_001260622.1  Rho-type guanine nucleotide exchange factor, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGB1
      Conserved Domains (5) summary
      cd11877
      Location:6 → 58
      SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
      cd00160
      Location:79 → 249
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:281 → 376
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
      pfam00169
      Location:294 → 372
      PH; PH domain
      pfam16614
      Location:543 → 610
      RhoGEF67_u2; Unstructured region two on RhoGEF 6 and 7

    8. NM_001382006.1 → NP_001369133.1  Rho-type guanine nucleotide exchange factor, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DZ19
      Conserved Domains (3) summary
      cd11877
      Location:6 → 58
      SH3_PIX; Src Homology 3 domain of Pak Interactive eXchange factors
      cd00160
      Location:79 → 249
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01225
      Location:281 → 376
      PH_Cool_Pix; Cloned out of library/PAK-interactive exchange factor pleckstrin homology (PH) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8DZ19 A8DZ19
    A8DZ20 A8DZ20
    C3KGL5 C3KGL5
    M9PBE8 M9PBE8
    M9PGB1 M9PGB1
    O62527 O62527
    Q8SYV1 Q8SYV1
    Q9VIN1 Q9VIN1

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